Clodronate Disodium Capsules

This product is a bone metabolism regulator that can enter the hydroxyapatite crystals in the bone matrix. When osteoclasts dissolve the crystals, the drug is released, which can inhibit the activity of osteoclasts and indirectly inhibit bone resorption through osteoblasts.

The main ingredient of this product is chlorthalidone. Its chemical name is 5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoazaindene-1-yl)-2-chlorobenzenesulfonamide.

Capsules, the contents are white crystalline powder.

Guling is suitable for the treatment of hypercalcemia and osteolysis caused by malignant tumors.

Oral administration: Patients with malignant tumors: 2.4g per day, divided into 2-3 doses. For patients with normal serum calcium levels, it can be reduced to 1.6g per day. If accompanied by hypercalcemia, it can be increased to 3.2g per day. It must be taken on an empty stomach, preferably 1 hour before meals. Early or all types of osteoporosis without bone pain: 0.4g per day, 3 months as a course of treatment, and the course can be repeated if necessary. Severe or all types of osteoporosis with bone pain: 1.6g per day, divided into two doses, or follow the doctor's advice.

1. Dizziness and fatigue may occur in a few cases, but they usually disappear with continued treatment. 2. Adverse reactions such as increased serum lactate dehydrogenase and other liver enzyme levels, leukopenia, and abnormal renal function may sometimes occur.

1. Patients who are allergic to this product are prohibited from using this product. 2. Patients with severe renal impairment and osteomalacia are prohibited from using this product.

Precautions for children: Long-term use of the drug in children may affect bone metabolism and should be used with caution. Precautions for pregnancy and lactation: Safety is not yet clear and it is not suitable for use. Precautions for the elderly: There is no special dosage recommendation for the elderly. Clinical trials have included patients over 65 years old, and no special adverse reactions have been reported in this age group.

Not yet clear

Sealed, store in a dry place.

0.2 g (calculated as CH2Cl2Na206P2)

60 months

Nanjing Pharmaceutical FACTORY Co., Ltd.

• Founded in:

  1991-07-11

• Address:

  No. 26, Xingang Avenue, Nanjing Economic and Technological Development Zone

• Tax NO.:

  91320192134908655F

• Registered Funds:

  200.8 million yuan

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