Calcium folinate injection

This product is a formyl derivative of tetrahydrofolate, mainly used for the rescue of high-dose methotrexate and other folic acid antagonists. The main function of methotrexate is to bind to dihydrofolate reductase, blocking the conversion of dihydrofolate into tetrahydrofolate, thereby inhibiting DNA synthesis. After entering the body, this product is converted into tetrahydrofolate by tetrahydrofolate reductase, which can effectively counteract the toxic reaction caused by methotrexate, but has no obvious effect on the existing methotrexate neurotoxicity.

The main component of this product is calcium folinate, and its chemical name is: N-[4-[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl-L-glutamic acid calcium salt pentahydrate. Its structural formula is: Molecular formula: C20H21CaN7O75H2O Molecular weight: 601.61.

This product is a yellow, clear aqueous solution.

1. Uracil combined use can improve the efficacy of fluorouracil, and is commonly used in the treatment of colorectal cancer and gastric cancer. 2. As an antidote for folic acid antagonists (such as methotrexate, pyrimethamine or trimethoprim). This product is commonly used in the clinic to prevent severe toxic effects caused by high-dose treatment such as methotrexate overdose. 3. For megaloblastic anemia caused by stomatitis, diarrhea, malnutrition, pregnancy or infancy, when oral folic acid is ineffective. It is not suitable for vitamin B12 deficiency anemia.

1 Used for 5-Fu combination enhancement, 20~500mg/m2 each time, intravenous drip, once a day, for 5 consecutive days. It can be diluted with normal saline or glucose injection to make an infusion solution, and the pH of the prepared infusion solution must not be less than 6.5. The infusion solution must be freshly prepared. 2 As a "rescue" therapy for methotrexate, the dosage of this product is best determined based on blood drug concentration. The generally used dosage is 9mg~15mg/m2 based on body surface area, intramuscular or intravenous injection, once every 6 hours, for a total of 12 times; as an antidote for pyrimethamine or trimethoprim, each dose is 9mg~15mg intramuscular injection, depending on the poisoning situation.

Rarely, other allergic reactions such as rash, hives, or asthma may occur.

Megaloblastic anemia caused by pernicious anemia or vitamin B12 deficiency.

The use of this product in large doses together with barbiturates, primidone or phenytoin sodium may affect the anti-epileptic effect.

Keep away from light and store at 2-8°C.

10 ml: 0.1 g