Piperacillin Sodium for Injection

Piperacillin is a semi-synthetic penicillin antibiotic with a broad-spectrum antibacterial effect. Piperacillin has good antibacterial effects on Enterobacteriaceae such as Escherichia coli, Proteus, Serratia, Klebsiella, Enterobacter, Citrobacter, Salmonella and Shigella, as well as other Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, Haemophilus influenzae and Neisseria. This product also has certain antibacterial activity against Enterococci, Group A and Group B hemolytic streptococci, Streptococcus pneumoniae and Staphylococci that do not produce penicillinase. Many anaerobic bacteria, including Bacteroides fragilis and Clostridium, are also sensitive to piperacillin. The mechanism of action of piperacillin is to exert a bactericidal effect by inhibiting bacterial cell wall synthesis.

Piperacillin Sodium

This product is white or off-white powder or loose lumps; odorless; highly hygroscopic.

It is suitable for sepsis caused by sensitive Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter, upper urinary tract and complicated urinary tract infections, respiratory tract infections, biliary tract infections, abdominal infections, pelvic infections, and skin and soft tissue infections. Piperacillin combined with aminoglycosides can also be used for infections in immunocompromised patients with neutropenia.

This product can be used for intramuscular injection, intravenous drip and intravenous injection. For moderate infection in adults, take 8g a day (0.5g, 16 sticks; 1.0g, 8 sticks; 2.0g, 4 sticks), divided into 2 intravenous drips; for severe infection, take 3-4g once (0.5g, 6-8 sticks; 1.0g, 3-4 sticks; 2.0g, 1.5-2 sticks), intravenous drip or injection every 4-6 hours. The total daily dose should not exceed 24g (0.5g, 48 sticks; 1.0g, 24 sticks; 2.0g, 12 sticks). The dose for infants and children under 12 years old is 100-200mg/kg per day based on body weight. For newborns weighing less than 2kg, take 50mg/kg every 12 hours in the first week after birth, by intravenous drip; from the second week onwards, take 50mg/kg once every 8 hours. For newborns weighing more than 2 kg, give 50 mg/kg by intravenous drip every 8 hours in the first week after birth; for those weighing more than 1 week old, give 50 mg/kg every 6 hours.

1. Allergic reactions: Allergic reactions to penicillins are common, including urticaria and other types of rashes, leukopenia, interstitial nephritis, asthma attacks and serum sickness reactions. In severe cases, anaphylactic shock is occasionally seen. Once anaphylactic shock occurs, emergency treatment must be given on the spot, including maintaining airway patency, oxygen inhalation, and administration of epinephrine, glucocorticoids and other treatment measures. 2. Local symptoms: pain at the local injection site, thrombophlebitis, etc. 3. Gastrointestinal symptoms: diarrhea, loose stools, nausea, vomiting, etc.; pseudomembranous colitis is rare. 4. Cholestatic jaundice may occur in some patients. 5. Central nervous system symptoms: headache, dizziness and fatigue, etc. 6. When a large dose is used in patients with impaired renal function, penicillin encephalopathy may occur due to increased cerebrospinal fluid concentration, so the dose should be adjusted according to renal function. 7. Others: Candida superinfection, bleeding, etc.

It is contraindicated in patients with a history of allergy to penicillins or a positive penicillin skin test.

1. In vitro, this product has a synergistic antibacterial effect against Pseudomonas aeruginosa and some Enterobacteriaceae when used in combination with aminoglycosides (amikacin, gentamicin or tobramycin). 2. This product is used in combination with cefoxitin, which can induce bacteria to produce β-lactamase and thus has an antagonistic effect against Pseudomonas aeruginosa, Serratia, Proteus and Enterobacter. 3. When used in combination with anticoagulants such as heparin, coumarin, indandione and non-steroidal anti-inflammatory analgesics, the risk of bleeding may be increased, and when used in combination with suppository solvents, severe bleeding may occur. 4. This product cannot be infused in the same bottle with aminoglycoside antibiotics, otherwise the antibacterial activity of both will be weakened.

Keep tightly closed in a cool, dark and dry place.

1.0g (calculated as C23H27N5O7S)

Shandong Lukang Pharmaceutical Co., Ltd.

• Founded in:

  1993-02-15

• Address:

  No. 88, Deyuan Road, Jining High-tech Zone, Shandong Province

• Tax NO.:

  913700001659297311

• Registered Funds:

  880.229735 yuan

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