Chloroquine Phosphate Tablets

Chloroquine mainly acts on erythrozoites, and after 48 to 72 hours, the schizonts in the blood are killed. This product is ineffective against the infrared stage of Plasmodium vivax malaria, so it cannot cure Plasmodium vivax malaria. It can cure falciparum malaria. Chloroquine is ineffective against the infrared stage and has no direct effect on gametocytes, so it cannot be used for etiology prevention and interruption of transmission.

Chemical name: Nˊ, Nˊ-diethyl-N4-(7-chloro-4-quinolyl)-1,4-pentanediamine diphosphate Molecular formula: C18H26ClN3·2H3PO4 Molecular weight: 515.87

This product is white tablets or white sugar-coated tablets.

This product is used to treat chloroquine-sensitive malignant malaria, vivax malaria and malaria malaria. It can also be used to suppress the symptoms of malaria. It can also be used to treat extraintestinal amebiasis, connective tissue diseases, photosensitivity diseases (such as sunburn erythema), etc.

1. Common dosage for adults (1) For vivax malaria, take 1g orally as the first dose, and 0.75g on the second and third days. (2) For suppressive prevention of malaria, take 0.5g orally once a week. (3) For extraintestinal amebiasis, take 1g orally daily, and change to 0.5g daily after 2 consecutive days. The total course of treatment is 3 weeks. (4) For rheumatoid arthritis, take 0.25-0.5g daily, and change to 0.125g 2-3 times a day after the symptoms are controlled. It takes 6 weeks to 6 months to achieve the maximum therapeutic effect. It can be used as an auxiliary drug for salicylic acid preparations and when adrenocortical hormones are tapered. 2. Common dosage for children (1) For vivax malaria, take the first oral dose of 10mg/kg body weight (calculated as chloroquine, the same below), and the maximum dose does not exceed 600mg. Take another dose of 5mg/kg body weight 6 hours later, and take 5mg/kg body weight daily on the second and third days. (2) For extraintestinal amebiasis, take 10 mg/kg of body weight orally daily (maximum dose not exceeding 600 mg), divided into 2 to 3 doses, for 2 weeks. After a 1-week break, the course of treatment can be repeated.

1. When this product is used to treat malaria, there are fewer adverse reactions. Oral administration generally has the following possible reactions: dizziness, headache, blurred vision, loss of appetite, nausea, vomiting, abdominal pain, diarrhea, itchy skin, rash, even exfoliative dermatitis, tinnitus, irritability, etc. Most reactions are mild and disappear on their own after stopping the drug. 2. When treating paragonimiasis, clonorchiasis and connective tissue diseases, the dosage is large and the course of treatment is long, and there may be more severe reactions. The most common one is eye toxicity, because chloroquine can be secreted by the lacrimal glands and absorbed by the cornea, and diffuse white particles appear on the cornea, which can disappear after stopping the drug. 3. A considerable part of this product accumulates in the tissues. Long-term use can cause mild retinal edema and pigment aggregation, dark spots, and affect vision, which is often irreversible. 4. Chloroquine can also damage hearing. Taking a large amount of chloroquine in pregnant women can cause congenital deafness, mental retardation, hydrocephalus, limb defects, etc. in children. 5Chloroquine may occasionally cause inhibition of the sinoatrial node, leading to arrhythmia and shock. In severe cases, it may cause Adams-Stokes syndrome and lead to death. 6This product may also cause drug-induced psychosis, leukopenia, purpura, rash, dermatitis, photosensitive dermatitis and even exfoliative dermatitis, psoriasis, hair whitening, hair loss, neuromuscular pain, mild transient headache, etc. 7Hemolysis, aplastic anemia, reversible granulocytosis, thrombocytopenia, etc. are relatively rare.

Pregnant women are strictly prohibited from using.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not for use by pregnant women, use with caution by lactating women. Precautions for the elderly: Not yet clear.

1. This product can easily cause allergic dermatitis when used with phenylbutazone; 2. It can easily increase the burden on the liver when used with chlorpromazine; 3. This product has a direct inhibitory effect on neuromuscular junctions, and streptomycin can aggravate this adverse reaction; 4. The use of this product after digitalization can easily cause heart block; 5. This product can increase the chance of bleeding when used with heparin or penicillamine; 6. This product can cure vivax malaria when used with primaquine. 7. When used with ammonium chloride, it can accelerate excretion and reduce blood concentration; 8. When used with monoamine oxidase inhibitors, it can increase toxicity; 9. When used with flurandrenolide, it can easily cause exfoliative erythroderma; 10. When used with chloroquine analogs (aminoquine, hydroxychloroquine, etc.), the blood concentration of chloroquine can be increased.

Keep away from light, tightly closed, in a cool place.

0.25g

24 months

Shenzhen Zhonglian Pharmaceutical Co., Ltd.

• Founded in:

  1988-10-11

• Address:

  Room 401, Building 1, Block B, No. 9 Danqing Road, Jinsha Community, Kengzi Street, Pingshan District, Shenzhen (One license, multiple locations enterprise)

• Tax NO.:

  91440300192188676Y

• Registered Funds:

  120 million yuan

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