Ketoprofen sustained-release capsules

This product is an aromatic propionic acid derivative and a non-steroidal anti-inflammatory analgesic. In addition to inhibiting cyclooxygenase, this product also has a certain effect of inhibiting lipoxygenase and reducing bradykinin, thereby reducing the pain sensation at the site of inflammatory injury. Because bradykinin and prostaglandins can cause pain together. Bradykinin can also cause uterine contraction, so this product is used for dysmenorrhea, mainly by inhibiting bradykinin, thereby inhibiting uterine contraction and analgesia to achieve therapeutic effects. This product also has a certain central analgesic effect. Acute toxicity test results: rat oral LD50 is 101mg/kg.

The main ingredients of this product and their chemical names are: The main ingredient of this product is ketoprofen, and its chemical name is ?-methyl-3-benzoyl-phenylacetic acid.

This product is a hard capsule containing small white pills.

Used for various arthritis: joint pain and swelling caused by rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gouty arthritis, etc., as well as various pains such as dysmenorrhea, toothache, postoperative pain, cancer pain, etc.

Adult oral administration: 75mg-100mg each time, twice a day or 0.2g (1 capsule) once a day. The maximum daily dose should not exceed 0.2g (1 capsule). To avoid gastrointestinal irritation, it should be taken after meals and the capsule should be swallowed whole.

1 Gastrointestinal reactions are more common, such as stomach pain or discomfort, bloating, nausea, vomiting, loss of appetite, diarrhea, constipation, etc. In severe cases, upper gastrointestinal ulcers, bleeding and perforation may occur. 2 Allergic reactions: allergic dermatitis, skin itching, exfoliative dermatitis, laryngeal edema, bronchospasm (allergic), etc. 3 Eyes: blurred vision, retinal hemorrhage 4 Cardiovascular system: arrhythmia, increased blood pressure, palpitations 5 Central nervous system: dizziness, headache, tinnitus, hearing loss, mental tension, depression, hallucinations, drowsiness, numbness of limbs, etc. 6 Liver and kidney: liver damage, decreased renal function, interstitial nephritis, kidney disease 7 Blood system: epistaxis, granulocytopenia, thrombocytopenia, hemolytic anemia, etc. 8 Others: water retention (rapid weight gain, decreased urine volume, facial edema, etc.), stomatitis, hyperhidrosis, etc.

1. Those who are allergic to aspirin or other non-steroidal anti-inflammatory drugs; 2. Those with active peptic ulcer.

Precautions for children: Not clear. Precautions for pregnancy and lactation: Contraindicated for pregnant and lactating women. Precautions for the elderly: When the elderly use this product, the plasma protein binding rate and drug excretion rate may be reduced, resulting in increased blood drug concentration and prolonged half-life, so attention should be paid to dosage adjustment.

1. Drinking alcohol or taking it with other non-steroidal anti-inflammatory drugs will increase gastrointestinal adverse reactions and bleeding tendency. 1. Long-term use with acetaminophen may increase the toxic side effects on the kidneys; 2. Use with anticoagulants such as heparin and dicoumarol and platelet aggregation inhibitors may increase the risk of bleeding; 3. When used with furosemide, the latter's sodium excretion and antihypertensive effects are weakened; 4. When used with verapamil and nifedipine, the blood concentration of this product increases; 5. This product can increase the blood concentration of digoxin, and the dose of digoxin should be adjusted when used together; 6. This product can enhance the effect of oral antidiabetic drugs; 7. When used with antihypertensive drugs, this product may affect the antihypertensive effect of the latter; 8. This product should not be used with probenecid, because the latter can significantly reduce the renal clearance rate of this product (reduced by 66%) and protein binding rate (reduced by 28%), resulting in increased blood concentration, which may cause poisoning; 9. This product can reduce the excretion of methotrexate, increase its blood concentration, and even reach toxic levels, so this product should not be used with medium or large doses of methotrexate.

Keep in a dark, airtight container in a cool place.

75mg

24 months