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Ampicillin Probenecid Capsules

Function and Efficacy

Ampicillin is the bactericidal component of this product. It acts on the active reproduction stage of bacteria and has a bactericidal effect by inhibiting the biosynthesis of cell wall mucopeptides. Probenecid is a benzoic acid derivative. It competes with ampicillin for the same active transport carrier in the renal tubules, inhibits the latter's excretion from the renal tubules, increases the blood concentration of ampicillin, and prolongs its half-life. This product is effective against a variety of Gram-positive and Gram-negative bacteria. Positive bacteria include: Staphylococcus aureus, Staphylococcus epidermidis (including resistant and some methicillin-resistant strains), pneumococcus, fecal streptococcus and other streptococci. Negative bacteria include Escherichia coli, Haemophilus influenzae, Branhamella catarrhalis, Escherichia coli, Klebsiella, Proteus mirabilis, etc. Anaerobic bacteria include Bacillus fragilis.

Ingredients

This product is a compound preparation, each tablet contains the active ingredients ampicillin 194.5 mg and probenecid 55.5 mg.

Name Description Content CAS NO. Manufacturer
AmpicillinIngredients

It acts on the active reproduction stage of bacteria and has a bactericidal effect by inhibiting the biosynthesis of cell wall mucopeptides.

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69-53-4 26
ProbenecidIngredients

Compete with ampicillin for the same active transporter in the renal tubules, inhibit the latter's excretion from the renal tubules, increase the blood concentration of ampicillin, and prolong its half-life

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57-66-9 8

Appearance

This product is a hard capsule, and the contents are white powder.

Indication

This product is suitable for the following infections caused by sensitive pathogenic bacteria: 1. Respiratory tract infections: upper respiratory tract infections, bacterial pneumonia, bronchitis, etc.; 2. Urinary tract infections: cystitis, urethritis, pyelonephritis, prostatitis, etc.; 3. Digestive tract infections: bacterial dysentery, etc.; 4. Ear, nose and throat infections: acute pharyngitis, tonsillitis, otitis media, sinusitis, etc.; 5. Skin and soft tissue infections; 6. Gonorrhea.

Usage and Dosage

For adults, take orally: 0.75 g at a time, 3 times a day. For gonorrhea: take orally 4.5 g (3.5 g ampicillin, 1 g probenecid) at a time.

Adverse Reactions

The adverse reactions of this product are mild, mainly including glossitis, gastritis, nausea, vomiting, enteritis, diarrhea, pseudomembranous colitis, mild abdominal pain and other gastrointestinal reactions and rashes, and occasionally transient increase in serum alanine aminotransferase (ALT).

Precautions

1. Patients who are allergic to penicillins or cephalosporins or have a positive penicillin skin test are prohibited from using this product. 2. Patients with uric acid kidney stones, acute gout attacks, and active gastrointestinal ulcers are prohibited from using this product. Children under 32 years old are prohibited from using this product.

Special Population Medication

Precautions for children: Not for use in children under 2 years old Precautions for pregnancy and lactation: Not for use. Precautions for the elderly: Due to the decline of physiological renal function, the dosage should be appropriately reduced.

Drug Interactions

The following drugs may interact with this product when taken at the same time: allopurinol, chloramphenicol, erythromycin, sulfonamides, tetracycline, oral contraceptives, dapsone, rifampicin, anti-inflammatory drugs, methotrexate, oral hypoglycemic drugs, naproxen, salicylates, pyrazinamide, etc. If you must take the above drugs at the same time, follow the doctor's advice.

Storage

Keep away from light, tightly closed, in a cool and dry place. Validity period: 18 months

Packaging Specification

0.25g (ampicillin 0.1945g and probenecid 0.0555g)

Validity Period

36 months

Manufacturer

Guangdong Qiling Pharmaceutical Co., Ltd.

  • Founded in:

    2006-01-13
  • Address:

    Hongguang Village, Yunluo Town, Puning City, Guangshan Highway
  • Tax NO.:

    91445281784898620J
  • Registered Funds:

    20 million yuan
  • Email:

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