Latamoxef Sodium for Injection

This product is a new type of semi-synthetic β-lactam broad-spectrum antibiotic. Its mechanism of action is to bind to the target protein on the cell membrane, making it impossible for bacteria to maintain their normal form and normal division and reproduction, and finally lyse and die. Since this product is extremely stable to β-lactamase, it has strong antibacterial activity against Gram-negative bacteria and anaerobic bacteria, but slightly weaker against Gram-positive bacteria, and also has a certain antibacterial effect on Pseudomonas aeruginosa.

The main ingredient of this product is latamoxef sodium; its chemical name is (6R,7R)-7-[2-carboxy-2-(4-hydroxyphenyl)acetylamino]-7-methoxy-3-[(1-methyl-1H-tetrazolyl-5-yl)thiomethyl]-8-oxo-5-oxa-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid disodium salt. [Molecular formula] C20H18N6Na2O9S [Molecular weight] 564.45

It is used for various infections caused by sensitive bacteria, such as sepsis, meningitis, respiratory system infections (pneumonia, bronchitis, bronchiectasis, pulmonary suppuration, empyema, etc.), digestive system infections (choledochitis, cholecystitis, etc.), intra-abdominal infections (liver abscess, peritonitis, etc.), urinary system and reproductive system infections (pyelonephritis, cystitis, urethritis, gonorrhea, epididymitis, intrauterine infection, adnexitis, pelvic inflammatory disease, etc.), skin and soft tissue infections, bone and joint infections and trauma infections.

Intravenous drip, intravenous injection or intramuscular injection, 1-2g (2-4 bottles) per day for adults, divided into 2 times; 40-80mg/kg per day for children, divided into 2-4 times, and appropriately increased or decreased according to age, weight, and symptoms. In case of refractory or severe infection, the dosage is increased to 4g (8 bottles) per day for adults and 150mg/kg per day for children, divided into 2-4 times. Before intravenous injection, 0.5g of this product is fully shaken with more than 4ml of sterile water for injection, 5% glucose injection or 0.9% sodium chloride injection to dissolve it completely; for intramuscular injection, shake it with 2-3ml of 0.5% lidocaine injection to dissolve it completely. After deep dissolution, use it as soon as possible. If it needs to be stored, store it in the refrigerator within 72 hours, and store it at room temperature within 24 hours.

This product has mild adverse reactions, and anaphylactic shock rarely occurs. The main adverse reactions include rash, urticaria, itching, nausea, vomiting, diarrhea, abdominal pain, etc., and occasional elevation of transaminase (SGPT, SGOT), which will disappear on their own after stopping the drug.

Patients with a history of allergic reaction to this product or cephalosporins are contraindicated.

(1) The combined use of this product with anticoagulants such as heparin and drugs that affect platelet aggregation such as aspirin and diflunisal may increase bleeding tendency. (2) This product should not be used simultaneously with strong diuretics to avoid increasing renal toxicity.

Seal and store in a cool, dark and dry place. The validity period is tentatively 2 years.

Calculated as C20H20N6O9S, 0.25g

Harbin Reputation Scale Pharmaceutical Co., Ltd.

• Founded in:

  2016-09-09

• Address:

  No. 29, Beijing Road, Limin Development Zone, Harbin

• Tax NO.:

  91230111MA19000W9R

• Registered Funds:

  402.0892 million yuan

• Email:

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