Doxapram Hydrochloride Injection
Function and Efficacy
This product is a respiratory stimulant. In small doses, it reflexively excites the respiratory center through the carotid body chemoreceptors. In large doses, it directly excites the medullary respiratory center, increasing the tidal volume and increasing the respiratory rate to a limited extent. Large doses excite the spinal cord and brainstem, but seem to have no effect on the cerebral cortex. When patients with obstructive pulmonary disease have acute ventilation insufficiency, the use of this drug can improve tidal volume, blood carbon dioxide partial pressure, and oxygen saturation.
Ingredients
The main ingredient of this product is doxapram hydrochloride, and its chemical name is: 1-ethyl-3,3-diphenyl-4-(2-morpholinoethyl)-2-pyrrolidone hydrochloride monohydrate.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Doxapram hydrochloride monohydrateIngredients |
This product is a respiratory stimulant. In small doses, it reflexively excites the respiratory center through the carotid body chemoreceptors. In large doses, it directly excites the medullary respiratory center, increasing the tidal volume and increasing the respiratory rate to a limited extent. Large doses excite the spinal cord and brainstem, but seem to have no effect on the cerebral cortex. When patients with obstructive pulmonary disease have acute ventilation insufficiency, the use of this drug can improve tidal volume, blood carbon dioxide partial pressure, and oxygen saturation. More |
7081-53-0 | 8 |
Appearance
This product is a colorless clear liquid.
Indication
For respiratory failure.
Usage and Dosage
Intravenous injection: 0.5~1.0mg/kg per body weight, not exceeding 1.5mg/kg. If repeated administration is required, at least 5 minutes interval is required. The hourly dosage should not exceed 300mg. Intravenous drip: 0.5~1.0mg/kg per body weight, diluted with glucose and sodium chloride injection before use, and then dripped intravenously until the therapeutic effect is achieved. The total amount should not exceed 3g per day.
Adverse Reactions
Headache, weakness, nausea, vomiting, sweating, feeling very hot, diarrhea, and urinary retention.
Precautions
Patients with convulsions, epilepsy, severe hypertension, pheochromocytoma, hyperthyroidism, coronary heart disease, intracranial hypertension, and severe lung disease.
Drug Interactions
1. This product can promote the release of catecholamines. It can only be used 10 to 20 minutes after general anesthetics such as halothane and isoflurane are discontinued. 2. When this product is used in combination with caffeine, methylphenidate, pemoline, adrenergic receptor agonists, etc., tension, excitement, insomnia, and even convulsions or arrhythmias may occur. 3. When this product is used in combination with monoamine oxidase inhibitors such as procarbazine and pressor drugs, blood pressure can be significantly increased.
Storage
Keep away from light and store in a sealed container.
Packaging Specification
5ml:100mg
Manufacturer
Xi`an Han Feng Pharmaceutical Co., Ltd.
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Founded in:
2003-03-11 -
Address:
No. 15, Wenji Road, Lantian County Industrial Park -
Tax NO.:
91610122742829723D -
Registered Funds:
25 million yuan -
Email: