Acyclovir capsules

Antiviral drug. It has an inhibitory effect on herpes simplex virus, varicella zoster virus, cytomegalovirus, etc. in vitro. After entering the cells infected by herpes virus, this product competes with deoxynucleoside for viral thymidine kinase or cell kinase, and the drug is phosphorylated into activated acyclovir triphosphate, and then inhibits viral replication in two ways: ① Interfering with viral DNA polymerase to inhibit viral replication; ② Under the action of DNA polymerase, it binds to the growing DNA chain, causing the extension of the DNA chain to be interrupted. This product has a special affinity for viruses, but has low toxicity to mammalian host cells. There are reports of carcinogenicity in in vitro cell transformation assays, but no evidence of carcinogenicity has been found in animal experiments. Some animal experiments show that high concentrations of drugs can cause mutations, but there is no evidence of chromosomal changes. The carcinogenic and mutagenic effects of this product are still unclear. High-dose injection can cause testicular atrophy and reduced sperm count in animals. The drug can pass through the placenta, and animal experiments have confirmed that it has no effect on the embryo.

The chemical name of the main ingredient of this product is: Acyclovir. Its chemical name is: 9-(2-hydroxyethoxymethyl)guanine. Molecular formula: C8H11N5O3 Molecular weight: 225.21

This product is in the form of capsules.

1. Herpes simplex virus infection: used for the initial and recurrent cases of genital herpes virus infection. For recurrent cases, this product can be taken orally for prevention. 2. Herpes zoster: used for the treatment of herpes zoster in people with normal immune function and mild cases in people with immunodeficiency. 3. Treatment of chickenpox in people with immunodeficiency.

Oral. 1. Genital herpes for the first time and mucocutaneous herpes simplex in immunocompromised patients: The usual dosage for adults is 0.2g (1 tablet) once, 5 times a day (5 tablets), for 10 days; or 0.4g (2 tablets) once, 3 times a day (6 tablets), for 5 days; for recurrent infection, 0.2g (1 tablet) once, 5 times a day (5 tablets), for 5 days; for chronic suppression therapy of recurrent infection, 0.2g (1 tablet) once, 3 times a day (3 tablets), for 6 months, and if necessary, the dosage can be increased to 5 times a day (5 tablets), 0.2g (1 tablet) once, for 6 to 12 months. 2. Herpes simplex: The usual dosage for adults is 0.8g once, 5 times a day, for 7 to 10 days. 3 Adult patients with insufficiency should adjust the dose according to the table below; Creatinine clearance (ml/minute) (ml/second) Dose (g) Dosing interval (hours) Genital herpes Initial or intermittent therapy 10 (0.17) 0.24 (5 times a day) 0-10 (0-0.17) 0.212 Chronic suppression therapy 10 (0.17) 0.4120-10 (0-0.17) 0.212 Herpes zoster 25 (0.42) 0.84 (5 times a day) 10-25 (0.17-0.42) 0.880-10 (0-0.17) 0.8124 Pox: Children over 2 years old should take 20 mg/kg of body weight once, 4 times a day, for 5 days. Start treatment immediately when symptoms appear. The usual dose for children over 40 kg and adults is 0.8 g once, 4 times a day, for 5 days.

Occasionally, dizziness, headache, joint pain, nausea, vomiting, diarrhea, stomach discomfort, loss of appetite, thirst, leukocytopenia, slight increase in proteinuria and urea nitrogen, skin itching, etc. may occur. Acne, insomnia, and menstrual disorders may occur occasionally with long-term administration.

It is contraindicated for those who are allergic to this product.

Precautions for children: No special adverse reactions have been found in children, but the dosage for children under 2 years old has not yet been determined. Precautions for pregnancy and lactation: The drug can pass through the placenta. Although animal experiments have confirmed that it has no effect on the embryo, pregnant women still need to weigh the pros and cons when using it. The concentration of the drug in breast milk is 0.6 to 4.1 times the blood concentration. Although no abnormalities have been found in infants, it is still advisable for lactating women to stop breastfeeding during the medication period. Precautions for the elderly: Due to the decline of physiological renal function, the dosage and medication interval of this product need to be adjusted.

1. Combination with zidovudine can cause nephrotoxicity, manifested as deep lethargy and fatigue. 2. Competitive inhibition of organic acid secretion with probenecid. Combination with probenecid can slow down the excretion of this product, prolong the half-life, and accumulate the drug in the body.

Keep tightly closed in a cool, dry place.

0.2g

36 months

Hangzhou Wanbang Tiancheng Pharmaceutical Co., Ltd.

• Founded in:

  2015-04-15

• Address:

  No. 1 Chunjiang Road, Qiaonan District, Xiaoshan Economic and Technological Development Zone, Xiaoshan District

• Tax NO.:

  91330109328248034G

• Registered Funds:

  10 million yuan

• Email:

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