Acyclovir capsules

This product is an antiviral drug. In vitro, it has inhibitory effects on herpes simplex virus, herpes zoster virus, cytomegalovirus, etc. After entering the cells infected with herpes virus, this product competes with deoxynucleoside for viral thymidine kinase or cellular kinase, and the drug is phosphorylated into activated acyclovir triphosphate, which then inhibits viral replication in two ways: ① Interfering with viral DNA polymerase to inhibit viral replication; ② Under the action of DNA polymerase, it binds to the growing DNA chain, causing the extension of the DNA chain to be interrupted. This product has a special affinity for viruses, but has low toxicity to mammalian host cells. There are reports of carcinogenicity in in vitro cell transformation assays, but no evidence of carcinogenicity has been found in animal experiments. Some animal experiments show that high concentrations of drugs can cause mutations, but there is no evidence of chromosomal changes. Carcinogenicity of this product

The main ingredient of this product is acyclovir, and its chemical name is: 9-[(2-hydroxyethoxy)methyl]guanine

This product is in the form of capsules.

1. Herpes simplex virus infection: used for the initial and recurrent cases of genital herpes virus infection. For recurrent cases, this product can be taken orally for prevention. 2. Herpes zoster: used for the treatment of herpes zoster in people with normal immune function and mild cases in people with immunodeficiency. 3. Treatment of chickenpox in people with immunodeficiency.

Oral 1. For the first treatment of genital herpes and mucocutaneous herpes simplex in immunocompromised patients: The usual dose for adults is 0.2g (1 tablet) once, 5 times a day (5 tablets), for 10 days; or 0.4g (2 tablets) once, 3 times a day (6 tablets), for 5 days; for recurrent infection, 0.2g (1 tablet) once, 5 times a day (5 tablets). For 5 days; for chronic suppressive therapy of recurrent infection, 0.2g (1 tablet) once, 3 times a day (3 tablets), for 6 months, if necessary, the dose can be increased to 5 times a day (5 tablets), 0.2g (1 tablet) once, for 6-12 months. 2. Herpes zoster: The usual dose for adults is 0.8g once, 5 times a day, for 7-10 days. 3. Adults with renal insufficiency

Occasionally, there may be dizziness, headache, joint pain, nausea, vomiting, diarrhea, stomach discomfort, loss of appetite, thirst, decreased white blood cell count, slight increase in proteinuria and urea nitrogen, skin pain and itching, etc. Long-term administration may occasionally cause acne, insomnia, and menstrual disorders.

1. It is contraindicated for patients who are allergic to acyclovir.

Precautions for children: The dosage for children under 2 years old has not been determined. Precautions for pregnancy and lactation: The drug can pass through the placenta. Although animal experiments have confirmed that it has no effect on the embryo, pregnant women still need to weigh the pros and cons of using the drug. The concentration of the drug in breast milk is 0.6 to 4.1 times the blood concentration. Although no abnormalities have been found in infants, breastfeeding women should use it with caution. Precautions for the elderly: Due to the decline of physiological renal function, the dosage and medication interval of this product need to be adjusted.

1. Combined use with zidovudine can cause nephrotoxicity, manifested as deep lethargy and fatigue. 2. Competitive inhibition of organic acid secretion with probenecid. Combined use with probenecid can slow down the excretion of this product, prolong the half-life, and accumulate the amount of drug in the body.

Sealed and stored in a cool place.

0.2g

24 months

Dalian Merro Traditional Chinese Medicine Factory Co., Ltd.

• Founded in:

  1999-09-09

• Address:

  No. 19, Yingsheng Road, Ganjingzi District, Dalian City, Liaoning Province

• Tax NO.:

  91210200716917738B

• Registered Funds:

  99.605 million yuan

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