Levamisole Hydrochloride Granules

This product is the levorotatory form of tetramisole, which can selectively inhibit succinate dehydrogenase in the muscles of the worm, so that fumaric acid cannot be reduced to succinic acid, thereby affecting the anaerobic metabolism of the muscles of the worm and reducing energy production. When the worm comes into contact with it, it can depolarize the nerves and muscles, and the muscles will continue to contract and cause paralysis; the drug's cholinergic effect is conducive to the excretion of the worm. Its activity is about 1 to 2 times that of tetramisole (racemic form), but its toxic side effects are lower. In addition, the drug may have an inhibitory effect on the microtubule structure of the worm. target=_blank Levamisole also has immune regulation and immune excitation functions.

Main ingredient: Levamisole hydrochloride Chemical name: (S)-(-)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride Molecular formula: C11H12N2S·HCl Molecular weight: 240.76

This product is colorful soluble granules with sweet taste.

It has good efficacy against ascaris, hookworm, pinworm and strongyloidiasis. Since the single dose of this product has a high efficacy, it is suitable for group treatment. It is more active than ethopropazine against adult worms and microfilariae of Bancroftian filariasis, Malayan Brugia and Onchocerca volvulus, but the long-term efficacy is poor.

1. Ascaris: Oral, 1.5~2.5mg/kg for adults, taken on an empty stomach or before bedtime, 2~3mg/kg for children. 2. Hookworm: Oral, 1.5~2.5mg/kg, once a night, for 3 consecutive days. 3. Treatment of filariasis: 4~6mg/kg, divided into 2~3 doses, for 3 consecutive days.

Generally mild. Symptoms include nausea, vomiting, abdominal pain, etc. A few may experience taste disorders, fatigue, dizziness, headache, joint pain, confusion, insomnia, fever, flu-like symptoms, low blood pressure, vasculitis, rash, photosensitivity dermatitis, etc. Proteinuria is occasionally seen. Some may experience granulocytopenia and thrombocytopenia. A few may even develop agranulocytosis (often reversible), which often occurs in patients with rheumatism or tumors. In addition, it can cause immediate and Arthus allergic reactions, which may be atopic reactions caused by stimulating T cells. Individual cases may experience ataxia, paresthesia or blurred vision.

It is contraindicated in patients with impaired liver and kidney function, active hepatitis, early pregnancy, or pre-existing schistosomiasis.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.

1. Combined with pyrantel, it can treat severe hookworm infection and improve the effect of expelling American hookworm. 2. Combined with thiabendazole, it can treat mixed intestinal nematode infection. 3. Sequential use with diethylcarbamazine citrate can treat filarial infection. 4. It should not be used in combination with tetrachloroethylene to avoid increasing its toxicity.

Sealed, store in a cool, dry place.

10g:50mg

24 months

Youhua Pharmaceutical (Leshan) Co., Ltd.

• Founded in:

  2004-10-20

• Address:

  No. 2, Linjiang North Road, Leshan High-tech Zone, Sichuan Province

• Tax NO.:

  91511100MA6280126G

• Registered Funds:

  91 million yuan

• Email:

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