Probenecid Tablets

1. Inhibit the active reabsorption of urate in the renal tubules, increase the excretion of urate, reduce the concentration of urate in the blood, and thus reduce uric acid deposition. Prevent the formation of urate crystals, reduce joint damage, and promote the dissolution of urate that has already formed. This product has no anti-inflammatory or analgesic effects and is used to treat chronic gout. 2. It can competitively inhibit the secretion of weak organic acids (such as penicillin and cephalosporin) in the renal tubules, thereby increasing the blood concentration of these antibiotics and prolonging their duration of action. It can be used as an adjuvant for antibiotic treatment. 3. Acute toxicity test results: The oral LD50 for rats is 1600 mg/kg.

The main ingredient of this product is probenecid. Its structural formula is: Molecular formula: C13H19NO4S Molecular weight: 285.36

This product is white tablets.

It is used for (1) hyperuricemia with chronic gouty arthritis and tophi, but it must be ① glomerular filtration rate greater than 50-60 ml/min; ② no kidney stones or history of kidney stones; ③ non-acidic urine; ④ not taking salicylic acid drugs. (2) As an auxiliary drug for antibiotic treatment, when used with antibiotics such as penicillin, ampicillin, oxacillin, o-cloxacillin, nafcillin, etc., it can inhibit the excretion of these antibiotics, increase blood drug concentration and maintain it for a long time.

1 Oral. 2 Hyperuricemia of chronic gout: 0.25g once for adults, twice a day, and can be increased to 0.5g once, twice a day after one week. 3 To enhance the effect of penicillins: 0.5g once for adults, 4 times a day. For children aged 2 to 14 years or weighing less than 50kg, the first dose is 0.025g/kg of body weight or 0.7g/m2 of body surface area, and then 0.01g/kg or 0.3g/m2 each time, 4 times a day.

1 Gastrointestinal symptoms such as nausea or vomiting are seen in about 5% of users. It may occasionally cause peptic ulcers. 2 It can promote the formation of kidney stones. The urine pH should be kept between 6.0 and 6.5. Drink plenty of water and take drugs that alkalinize urine to prevent kidney stones. 3 This product has cross-allergic reactions with sulfonamides, including rash, itchy skin and fever, but it is rare. 4 It may occasionally cause rare adverse reactions such as leukopenia, bone marrow suppression and liver necrosis.

1. Those who are allergic to this product and sulfonamides. 2. Those with renal insufficiency. 3. Those with hyperuricemia accompanied by tumors, or patients using cytotoxic anticancer drugs or radiotherapy should not use this product because it may cause acute kidney disease.

Precautions for children: Children under 2 years old are prohibited. Precautions for pregnancy and lactation: This product can pass through the placenta and appear in the umbilical cord blood. Precautions for pregnant and lactating women are prohibited. Precautions for the elderly: Elderly patients should reduce the dosage due to decreased renal function.

1. Drinking alcohol, diuretics such as chlorthalidone, uric acid, furosemide, pyrazinamide and thiazide can increase serum uric acid concentration. When this product is used with these drugs, it is necessary to adjust the dosage to control hyperuricemia. 2. When used with aspirin or other salicylates, the uric acid excretion effect of this product can be inhibited. 3. When used with indomethacin, dapsone, naproxen, etc., the blood concentration of the latter increases, and the toxicity increases. 4. When used with various penicillins and cephalosporins, the blood concentration of the latter increases and lasts for a long time, and the toxicity increases, especially to the kidneys. 5. When used with oral hypoglycemic drugs, the effect of the latter is enhanced. 6. When used with methotrexate, the blood concentration of the latter may increase, and the toxicity increases. 7. When used with nitrofurantoin, the anti-infection efficacy of nitrofurantoin in urine is reduced due to the inhibition of renal tubular secretion. 8 When used with rifampicin, the two drugs compete for uptake by the liver, so the blood concentration of rifampicin can increase and last longer, and the toxicity increases. Clinically, it is generally not recommended to use the two drugs together to increase the blood concentration of rifampicin. 9 When used with sulfonamides, the latter's excretion by the kidneys slows down, and the blood concentration increases. When used together for a long time, the blood concentration of sulfonamides should be tested regularly.

Keep away from light and store in sealed container.

0.25g

24 months

Jinling Pharmaceutical Co., Ltd. Nanjing Jinling Pharmaceutical Factory

• Founded in:

  1996-09-16

• Address:

  No. 58, Xingang Avenue, Nanjing Economic and Technological Development Zone

• Tax NO.:

  9132019270413930XB

• Registered Funds:

  -

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