Chenodeoxycholic acid capsules
Function and Efficacy
The main function of CDCA is to reduce the saturation of cholesterol in bile. After taking CDCA for most patients (when CDCA accounts for 70% of bile salts in bile), lipids return to the micelle state and cholesterol is in an unsaturated state, thereby dissolving and falling off the cholesterol in the stones. Large doses of CDCA (10-15 mg/kg per day) can inhibit the synthesis of cholesterol and increase the secretion of bile in patients with cholelithiasis, but the secretion of bile salts and phospholipids remains unchanged.
Ingredients
Main ingredients and their chemical names: Chenodeoxycholic acid, chemical name 3alpha;, 7alpha;-dihydroxy-5beta;-cholanic acid
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Chenodeoxycholic acidIngredients |
Reduce the saturation of cholesterol in bile. After taking CDCA, most patients (when CDCA accounts for 70% of bile salts in bile), lipids return to the micelle state, and cholesterol is in an unsaturated state, so that the cholesterol in the stones dissolves and falls off. Large doses of CDCA (10-15 mg/kg per day) can inhibit the synthesis of cholesterol and increase the secretion of bile in patients with cholelithiasis, but the secretion of bile salts and phospholipids remains unchanged. More |
474-25-9 | 10 |
Appearance
It is white or light yellow crystalline powder with a peculiar odor.
Indication
It is used for cholesterol cholelithiasis and also has certain efficacy on bile pigment stones and mixed stones.
Usage and Dosage
Oral administration, adjust according to the condition, generally 12-15 mg/kg per day based on body weight, twice a day, with meals or milk; obese patients should increase the dosage slightly, up to 18-20 mg/kg per day, and the course of treatment is 6-24 months.
Adverse Reactions
The most common side effect is diarrhea (30% to 50%), which is characterized by cramps in the lower abdomen followed by watery stools. It is dose-related and disappears after the dose is reduced. Most patients can tolerate it if the dose is gradually increased. 2 A small number of patients (30%) may have a transient and reversible increase in AST (SGOT). 3 Some patients may experience skin itching, dizziness, nausea, and abdominal distension.
Precautions
Pregnant women, patients with enteritis or liver disease should not use it.
Special Population Medication
Precautions during pregnancy and lactation: Pregnant women are prohibited from using
Drug Interactions
1. Contraceptive pills can increase bile saturation. When using this product for treatment, other birth control measures should be taken as much as possible to avoid affecting the efficacy. 2. Cholestyramine (Cholestyramine), colestipol (Colestipol) and aluminum-containing antacids can bind to CDCA and reduce its absorption. They should not be used together.
Storage
Keep away from light, tightly closed, and stored in a dry and cool place.
Packaging Specification
0.25g
Manufacturer
Greenfield Pharmaceutical (Jiangsu) Co., Ltd.
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Founded in:
2002-08-07 -
Address:
No. 38, Taijiu Road, Taizhou City, Jiangsu Province -
Tax NO.:
91321200740650535K -
Registered Funds:
$4,166,286 -
Website:
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Email: