Cefaclor sustained-release tablets

This product is a broad-spectrum semi-synthetic cephalosporin antibiotic. Its activity against penicillinase-producing Staphylococcus aureus, group A hemolytic streptococci, viridans streptococci and Staphylococcus epidermidis is the same as that of cefadroxil, and its antibacterial effect against non-enzyme-producing Staphylococcus aureus and pneumococci is 2 to 4 times stronger than that of cefadroxil. Its activity against Gram-negative bacilli, including Escherichia coli and Klebsiella pneumoniae, is stronger than that of cefadroxil, and is similar to that of cefadroxil. Its activity against Proteus mirabilis, Salmonella and Shigella is stronger than that of cefadroxil. 2.9 to 8 mg/L of this product can inhibit all Haemophilus influenzae, including strains resistant to ampicillin. Moraxella catarrhalis and Neisseria gonorrhoeae are very sensitive to this product. Indole-positive Proteus, Serratia, Acinetobacter and Pseudomonas aeruginosa are all resistant to this product. The mechanism of action of this product is to inhibit the synthesis of bacterial cell walls.

The main ingredient of this product is cefaclor, and its chemical name is (6R,7R)-7-[(R)-2-amino-2-phenylacetylamino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate.

This product is a light yellow film-coated tablet, which appears white after removing the coating.

This product is suitable for the following mild and moderate infections caused by sensitive bacteria such as Staphylococcus aureus, hemolytic streptococci, pneumococcus, Escherichia coli pneumonia, influenza bacillus, Shigella dysenteriae, etc.: 1. Tonsillitis, peritonsillitis, pharyngitis, bronchitis, pneumonia, bronchopneumonia, asthma and bronchiectasis infection and postoperative infection. 2. Acute and chronic pyelitis, cystitis, prostatitis and genitourinary system infection. 3. Otitis media, otitis externa, sinusitis, hordeolum, blepharitis, acute dacryocystitis. 4. Maxillary periostitis, maxillary periostitis, maxillary osteomyelitis, alveolar abscess, apical periodontitis, wisdom tooth peritonitis, post-extraction infection. 5. Folliculitis, erysipelas, cellulitis, impetigo, acne infection, subcutaneous abscess, trauma infection, submastitis, lymphangitis.

Oral. Pneumonia: 750 mg once, twice a day. Other infections: 375 mg once, twice a day. For infections caused by group A streptococci, the course of treatment is at least 10 days. The dose for patients with moderate and severe renal impairment is reduced to 1/2 and 1/4 of the normal dose, respectively.

1. Common gastrointestinal reactions: soft stools, diarrhea, stomach discomfort, loss of appetite, nausea, vomiting, heating, etc. 2. Serum sickness-like reactions are more common than other antibiotics, especially in children, with typical symptoms including skin reactions and joint pain. 3. Allergic reactions: rash, urticaria, eosinophilia, vulvar itching, etc. 4. Others: mild increase in serum aminotransferase, urea nitrogen and creatinine, proteinuria, tubular urine, etc.

This product is contraindicated in patients who are allergic to cefaclor and other cephalosporins.

Precautions for children: The effectiveness and safety for children have not been established. Precautions for pregnancy and lactation: 1. Pregnant women should use with caution. 2. This product can be excreted through breast milk, so lactating women should use it with caution or stop breastfeeding. Precautions for the elderly: Elderly patients should adjust the dosage or medication interval according to their renal function under the guidance of a physician.

(1) If you take any other medicines, please inform your doctor or pharmacist, including any over-the-counter medicines purchased from pharmacies, supermarkets or health food stores. These medicines may be affected by this product, or this product may affect the efficacy of other medicines. You may need different doses or need to take different medicines. Please follow your doctor's advice. (2) Doctors and pharmacists may have more information on precautions when taking this product. (3) Some medicines (or foods) may interfere with this product, including: ① Strong diuretics such as furosemide, ethacrynic acid, bumetanide, anti-tumor drugs such as carmustine, streptozocin, and nephrotoxic drugs such as aminoglycoside antibiotics may increase nephrotoxicity when used in combination with this product. ② Clavulanic acid can enhance the antibacterial activity of this product against certain Gram-negative bacteria that are resistant to this product due to the production of β-lactamase. ③ Oral probenecid can delay the excretion of this product. ④ Do not take antacids containing magnesium and aluminum hydroxide within 1 hour of taking this drug. ⑤ Food can reduce the absorption of this product. When taken with food, the peak blood concentration is only 50% to 75% of that taken on an empty stomach.

Seal and store in a cool and dark place. Validity period: one and a half years

0.375g (calculated as C15H14ClN3O4S)

Tentatively 24 months.

Hunan Baicao Pharmaceutical Co., Ltd.

• Founded in:

  1996-11-15

• Address:

  No. 808, Lingling North Road, Lengshuitan District, Yongzhou City

• Tax NO.:

  91431103188519962A

• Registered Funds:

  19.81 million yuan

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