Captopril Tablets

This product is a competitive angiotensin converting enzyme inhibitor, which prevents angiotensin I from converting into angiotensin II, thereby reducing peripheral vascular resistance and reducing water and sodium retention by inhibiting aldosterone secretion. This product can also dilate peripheral blood vessels by interfering with the degradation of bradykinin. For patients with heart failure, this product can also reduce pulmonary capillary wedge pressure and pulmonary vascular resistance, increase cardiac output and exercise tolerance time. This product can be secreted through breast milk and can pass through the placenta.

Main ingredients: Captopril, hydrochlorothiazide, etc.

This product is white or off-white tablets.

1. Hypertension; 2. Heart failure.

It depends on the condition or individual differences. This product should be taken under the guidance or supervision of a physician. The dosage must follow the principle of individualization and be adjusted according to the efficacy. 1 Common dosage for adults: (1) For hypertension, take 12.5 mg orally once, 2-3 times a day. Increase to 50 mg 2-3 times a day within 1-2 weeks as needed. If the efficacy is still unsatisfactory, other antihypertensive drugs can be added. (2) For heart failure, start with 12.5 mg orally once, 2-3 times a day. If necessary, gradually increase to 50 mg 2-3 times a day. If further increase is needed, observe the efficacy for 2 weeks before considering it. For patients who have recently taken a large amount of diuretics and are in hyponatremia/hypovolemia, but have normal or low blood pressure, the initial dose should be 6.25 mg 3 times a day, and then gradually increase to the common dose through testing. 2 Common dosage for children: For lowering blood pressure and treating heart failure, start with 0.3 mg/kg body weight, 3 times a day. If necessary, increase the dosage by 0.3 mg/kg every 8-24 hours to obtain the lowest effective dose.

1. The more common ones are: (1) Rash, which may be accompanied by itching and fever. It often occurs within 4 weeks of treatment and is maculopapular or urticaria. It disappears after reducing the dose, stopping the drug or taking antihistamines. 7% to 10% are accompanied by eosinophilia or positive antinuclear antibodies. (2) Palpitations, tachycardia, chest pain. (3) Cough. (4) Taste loss. 2. Less common ones are: (1) Proteinuria, which often occurs within 8 months of the start of treatment. One quarter of them will develop nephrotic syndrome, but proteinuria will gradually decrease within 6 months and the course of treatment will not be affected. (2) Dizziness, headache, and syncope. It is caused by hypotension, especially when there is a lack of sodium or blood volume. (3) Angioedema, which occurs on the face and limbs. It can also cause angioedema of the tongue, glottis or larynx. Be vigilant. (4) Rapid and irregular heart rate. (5) Facial flushing or pallor. 3. Rare events include: leukocytopenia and granulocytopenia, fever, chills. The leukocytopenia is dose-related, occurring 3-12 weeks after the start of treatment, most significant at 10-30 days, and persisting for 2 weeks after stopping the drug.

Patients who are allergic to this product or other angiotensin-converting enzyme inhibitors are contraindicated.

Precautions for children: There have been reports that this product can cause excessive and persistent decreases in blood pressure in infants, accompanied by oliguria and convulsions, so the use of this product is limited to those who have not responded to other antihypertensive treatments. Precautions for pregnancy and lactation: 1. This product can pass through the placenta. 2. This product can be excreted into breast milk, and its concentration is about 1% of the maternal blood drug concentration, so lactating women must weigh the pros and cons when using it. 3. Pregnant women who absorb ACEⅠ can affect fetal development and even cause fetal death, so pregnant women are prohibited from using it. Precautions for the elderly: The elderly are more sensitive to antihypertensive effects, so the dosage of this product should be reduced as appropriate.

When used with diuretics, the antihypertensive effect is enhanced, but severe hypotension should be avoided. Therefore, those who originally used diuretics should stop taking them or reduce the dosage. This product is started with a small dose and the dosage is gradually adjusted. 1. Used with other vasodilators may cause hypotension. If used together, it should be started with a small dose. 2. Used with potassium-retaining diuretics such as spironolactone, triamterene, and amiloride may cause hyperkalemia. 3. Used with endogenous prostaglandin synthesis inhibitors such as indomethacin, the antihypertensive effect of this product will be weakened. 4. When used with other antihypertensive drugs, the antihypertensive effect is enhanced; it has an additive effect with drugs that cause renin release or affect sympathetic activity; it has a less than additive effect with b-blockers.

Keep tightly closed in a cool, dark and dry place.

25 mg

36 months.

Shanghai Hengshan Pharmaceutical Co., Ltd.

• Founded in:

  1981-07-20

• Address:

  No. 176, Zidong Road, Minhang District, Shanghai

• Tax NO.:

  91310112132628617W

• Registered Funds:

  47.46 million yuan

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