L-Carnitine Oral Solution

L-Carnitine is a natural substance in the body that is essential for mammalian energy metabolism. Its main function is to promote lipid metabolism. During ischemia and hypoxia, acyl-CoA accumulates, and long-chain acyl-Carnitine also accumulates in the mitochondria, while free Carnitine decreases due to large-scale consumption. Ischemia and hypoxia lead to a decrease in ATP levels, increased permeability of cell membranes and subcellular membranes, and accumulated acyl-CoA can cause changes in membrane structure, membrane phase collapse, and cell death. In addition, during hypoxia, sugar anaerobic glycolysis is the main process, and the accumulation of fatty acids leads to acidosis, ion disorder, and cell autolysis and death. A sufficient amount of free Carnitine can allow accumulated acyl-CoA to enter the mitochondria, reduce its inhibition of adenine nucleotide translocase, and enable oxidative phosphorylation to proceed smoothly. L-Carnitine is the main energy source for muscle cells, especially myocardial cells. Many tissues and organs such as the brain and kidneys also rely mainly on fatty acid oxidation for energy. Carnitine can also increase the activity of NADH cytochrome reductase and cytochrome oxidase, accelerate the production of ATP, and participate in the detoxification of certain drugs. For various tissue ischemia and hypoxia, L-carnitine improves the energy supply of tissues and organs by increasing energy production. Other functions of L-carnitine include: oxidation of medium-chain fatty acids; oxidation of fatty acid peroxidase; buffering the ratio of bound coenzyme A to free coenzyme A; generating energy from ketones, pyruvate, and amino acids (including branched-chain amino acids), removing the toxicity of excessive coenzyme A, and regulating blood ammonia concentration.

The main ingredient of this product is L-carnitine. Chemical name: (R)-3-carboxy-2-hydroxy-N, N, N-trimethyl-1-propylamine hydroxide. Molecular weight: C7H15N03

This product is a colorless clear liquid.

It is suitable for secondary carnitine deficiency. It is mainly used for various symptoms caused by carnitine deficiency in patients with chronic renal failure who undergo long-term hemodialysis or peritoneal dialysis. Clinical manifestations include cardiomyopathy, skeletal myopathy (pain), arrhythmia, hyperlipidemia, hypotension and muscle spasm during dialysis.

The daily dosage for adults is 1 to 3 g, and for children it is 50 to 100 mg per kilogram of body weight per day. The maximum daily dose should not exceed 3 g, and should be taken 1 to 3 times a day during or after meals.

Long-term use may cause mild gastrointestinal reactions, including transient nausea, vomiting, abdominal cramps and diarrhea; these reactions may be alleviated or disappear after reducing the dose. Close attention should be paid to the patient's tolerance during the first week of medication and when increasing the dose.

It is contraindicated for those who are allergic to this product.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.

Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.

Keep away from light and store in a sealed container at room temperature.

10 ml: 1 g

24 months

Changzhou Lanling Pharmaceutical Co., Ltd.

• Founded in:

  1979-01-01

• Address:

  No. 352, Laodong East Road, Changzhou

• Tax NO.:

  91320400137158984C

• Registered Funds:

  25 million yuan

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