Idarubicin Hydrochloride for Injection

This drug is an anthracycline antibiotic with antimitotic and cytotoxic effects. This drug is an anthracycline antibiotic with antimitotic and cytotoxic effects. Its mechanism of action is to act on topoisomerase II and inhibit nucleic acid synthesis. The change in the 4-position of the anthracene ring structure makes the compound lipophilic, which increases the cell's uptake of the drug.

The injection of this medicine is a pyrogen-free, orange-red freeze-dried powder in a bottle. In addition to the active ingredient, it also contains a small amount of lactose.

Induction of remission of adult acute non-lymphocytic leukemia, induction of remission of relapsed and refractory patients. Second-line treatment of adult and childhood acute lymphocytic leukemia, and can also be used in comprehensive chemotherapy regimens.

1. For acute non-lymphocytic leukemia, adults take 12 mg/m2/day for 3 days, in combination with cytarabine. Another method is to use it alone or in combination: 8 mg/m2/day, intravenous injection, for 5 days. 2. For acute lymphocytic leukemia, adults take 12 mg/m2/day for 3 days. Children take 10 mg/m2/day for 3 days. Intravenous injection. Based on the recommended dose, the amount after 2 courses of treatment can reach 60-80 mg/m2. Although there is no upper limit, the average dose to avoid cardiac events in cancer patients is 93 mg/m2.

Severe bone marrow suppression and cardiotoxicity, fatal infections. Reversible alopecia, gastrointestinal reactions such as nausea, vomiting, mucositis, especially oral mucositis, which occurs 3-10 days after treatment, esophagitis, diarrhea, fever, chills, rash. There are enzymes and bilirubin increase. Urine turns red after 1-2 days of using this drug.

Combination with other drugs that have bone marrow suppression may aggravate bone marrow suppression. It will degrade with alkaline solution. Combination with heparin will produce precipitation, so do not use with other drugs.

Keep tightly closed in a cool place.

5 mg

Pfizer Pharmaceutical Wuxi Co., Ltd.

• Founded in:

  1995-09-19

• Address:

  No. 7 Mashan Bridge, Binhu District, Wuxi City

• Tax NO.:

  913202006079219223

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