Compound Glycyrrhizin Tablets

1. Anti-inflammatory effect 1.1. Anti-allergic effect Glycyrrhizic acid glycoside has anti-allergic effects such as inhibiting local allergic necrosis reaction (Arthus Phenomenon) of rabbits and inhibiting Schwartzman phenomenon (Shwartzman Phenomenon). For corticosteroids, it enhances the hormone's inhibitory effect on stress response and antagonizes the hormone's anti-granulation and thymic atrophy effects. It has no effect on the exudation of hormones. 1.2. Inhibitory effect on arachidonic acid metabolic enzymes Glycyrrhizic acid glycoside can directly bind to phospholipase A2, the initiator enzyme of the arachidonic acid metabolic pathway, and to lipoxygenase, which acts on arachidonic acid to produce inflammatory mediators, selectively inhibiting the phosphorylation of these enzymes and inhibiting their activation. 2. Immunomodulatory effect Glycyrrhizic acid has the following immunomodulatory effects in in vitro experiments (invitro): 2.1. Regulation of T cell activation; 2.2. Induction of interferon Y; 2.3. Activation of NK cells; 2.4. Promoting the differentiation of extrathymic T lymphocytes. 3. Inhibition of experimental hepatocyte damage In the rat hepatocyte cell line cultured in invitro, glycyrrhizic acid has the effect of inhibiting hepatocyte damage caused by carbon tetrachloride. 4. Promoting hepatocyte proliferation In vitro experiments on primary cultured hepatocytes of Wistar rats showed that glycyrrhizic acid and glycyrrhetinic acid have the effect of promoting hepatocyte proliferation. 5. Inhibition of viral proliferation and inactivation of viruses In the dd strain mouse MHV (mouse hepatitis virus) infection experiment, the administration of glycyrrhizic acid can prolong their survival days. In the experiment of preventing the occurrence of vaccinia virus in rabbits, it has the effect of preventing the occurrence of acne; in the in vitro experiment, it has also been observed to inhibit the proliferation of herpes virus and the inactivation of viruses. It has been reported that glycine and methionine can inhibit the decrease in urine volume and sodium excretion caused by oral administration of glycyrrhizic acid to Wistar/KY rats.

This product is a compound preparation, each tablet containing 25 mg of glycyrrhizic acid (25.52 mg as monoammonium glycyrrhizinate), 25 mg of glycine, and 25 mg of methionine.

This product is an off-white sugar-coated tablet, which appears white or off-white after removing the coating.

Treat chronic liver disease and improve abnormal liver function. Can be used to treat eczema, dermatitis and alopecia areata.

Adults usually take 2-3 tablets each time, and children take 1 tablet each time, 3 times a day, after meals. The dosage can be increased or decreased according to age and symptoms.

The actual frequency of adverse reactions in the use of this preparation has not been investigated. Important adverse reactions Pseudoaldosteronism (frequency unknown): Pseudoaldosteronism symptoms such as hypokalemia, increased blood pressure, sodium and fluid retention, edema, decreased urine volume, and weight gain may occur. Therefore, during medication, it is necessary to observe carefully (serum potassium value, etc.), and if abnormal conditions are found, the medication should be stopped. In addition, symptoms of rhabdomyolysis such as weakness, low muscle strength, muscle pain, limb cramps, and paralysis may also occur. If CK (CPK) is found to be elevated, and myoglobin in blood and urine is elevated, the medication should be stopped and appropriate treatment should be given.

(The following patients should not be given this medicine) 1. Patients with aldosteronism, myopathy, and hypokalemia (it may aggravate hypokalemia and hypertension). 2. Patients with advanced liver cirrhosis who tend to have elevated blood ammonia (the metabolites of methionine contained in this preparation can inhibit urea synthesis, thereby reducing the ability to handle ammonia).

Precautions for children: Children take 1 tablet at a time, 3 times a day, orally after meals. Precautions for pregnancy and lactation: Pregnant and lactating women should be given the drug with caution after weighing the benefits of treatment outweigh the risks. Precautions for the elderly: Based on clinical application experience, the elderly are prone to adverse reactions of hypokalemia, so they need to be given with caution under close observation.

Be careful when using medications together.

Store at room temperature.

Each tablet contains 25 mg of glycyrrhizic acid, 25 mg of glycine and 25 mg of methionine.

24 months.

Germany Pharmaceutical Co., Ltd.

• Founded in:

  2010-12-06

• Address:

  No. 216, East Section of Ping'an Avenue, Xiangcheng City, Henan Province

• Tax NO.:

  914116005664681555

• Registered Funds:

  55 million yuan

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