Cimetidine

1. Pharmacology: It mainly acts on H2 receptors on parietal cells, competitively inhibiting histamine. It can inhibit basal gastric acid secretion. It can also inhibit gastric acid secretion stimulated by food, histamine, pentagastrin, caffeine and insulin. 2. Toxicology: Acute toxicity, oral LD50 for mice is 3190-3280 mg/Kg, and oral LD50 for rats is 5840-7500 mg/Kg. Subacute and chronic toxicity tests on rats and dogs have shown that this product has a mild anti-androgen effect and can cause a decrease in the weight of the prostate and seminal vesicles. Milk secretion occurs, but disappears after drug withdrawal. It has no mutagenic, carcinogenic, or teratogenic effects. It also has no dependence and drug resistance.

Cimetidine. Its chemical name is: N-methyl-N-[2[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]-N-cyanoguanidine. Molecular formula: C10H16N6S Molecular weight: 252.34

Used to treat duodenal ulcer, gastric ulcer, reflux esophagitis, stress ulcer and Zollinger-Ellison syndrome.

Oral administration: ① Adults: 200-400 mg each time, 800-1600 mg per day, usually taken once after meals and before bedtime, the course of treatment is generally 4-6 weeks. Others advocate taking the daily dose twice (400 mg each time) or taking it all at once (800 mg taken orally at night). ② Children: 5-10 mg/kg per day, 2-4 times a day, after meals, and take one more dose before bedtime for severe cases. You can also refer to the adult method and divide the daily dose into 2 times or once, the course of treatment is the same as above.

The adverse reactions of this product are generally uncommon, and usually disappear after continued medication or discontinuation of medication. 1. The more common adverse reactions include diarrhea, fatigue, dizziness, drowsiness, headache and rash. 2. This product has a mild anti-androgen effect. Larger doses (more than 1.6g per day) can cause male breast development, female galactorrhea, loss of libido, impotence, and decreased sperm count, which disappear after discontinuation of the drug. 3. This product can pass the blood-brain barrier and has certain neurotoxicity. Occasionally - mental disorders, anxiety, depression, worry, delirium, and disorientation are more common in elderly and critically ill patients, and the symptoms usually disappear 3-4 days after discontinuation of the drug. When treating gastrointestinal complications of alcoholics, delirium tremens may occur, which is very similar to alcohol withdrawal syndrome. 4. Rare adverse reactions of this product include: allergic reactions

It is contraindicated for pregnant and lactating women.

Precautions for children: Young children are prone to central nervous system toxicity, so it should be used with caution. Precautions for pregnancy and lactation: ① Because it can pass through the placental barrier and enter breast milk, it is forbidden for pregnant and lactating women to avoid causing liver dysfunction in the fetus and infant. Precautions for the elderly: The kidney is an important organ for the metabolism of this product. The clearance rate of this product through the kidney decreases with age. Therefore, the dose should be reduced for elderly patients to prevent the occurrence of toxic mental disorder.

① Taking this product at the same time as aluminum hydroxide, magnesium oxide or metoclopramide can reduce the blood concentration of this product. If it must be used in combination with antacids, the two should be taken at least 1 hour apart; if used in combination with metoclopramide, the dose of this product needs to be appropriately increased. ② Since sucralfate needs to be hydrolyzed by gastric acid to exert its effect, this product inhibits gastric acid secretion, and the combination of the two may reduce the efficacy of sucralfate. ③ This product can bind to cytochrome P450 through its imidazole ring, inhibit the activity of liver microsomal oxidase, and also reduce the blood flow into the liver. Therefore, when used in combination with propranolol, metoprolol, metronidazole, etc., the latter's serum concentration increases and the heart rate slows down at rest; when used in combination with phenytoin sodium or other hydantoins, the latter's blood concentration may increase.

Keep sealed.

Changzhou Kangpu Pharmaceutical Co., Ltd.

• Founded in:

  1979-12-01

• Address:

  No. 6, Jingde East Road, Qianhuang Town, Wujin District

• Tax NO.:

  91320412250816627K

• Registered Funds:

  20 million yuan

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