Clozapine

This product is a dibenzodiazepine antipsychotic. It has a strong blocking effect on the 5-hydroxytryptamine (5-HT2A) receptor and dopamine (DA1) receptor in the brain, and also has a blocking effect on the dopamine (DA4) receptor, and a weaker blocking effect on the dopamine (DA2) receptor. In addition, it also has anticholinergic (M1), antihistamine (H1) and anti-α-adrenaline receptor effects. Extrapyramidal reactions are rare, and generally do not cause an increase in blood prolactin. It can directly inhibit the ascending activation system of the brainstem reticular formation and has a strong sedative and hypnotic effect.

The main ingredient of this product is clozapine, and its chemical name is: 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine.

This product is light yellow tablet.

This product is not only effective for positive symptoms of psychosis, but also has a certain effect on negative symptoms. It is suitable for various subtypes of acute and chronic schizophrenia, and has good effects on hallucination and delusional types and adolescent types. It can also alleviate the emotional symptoms related to schizophrenia (such as depression, guilt, and anxiety). For some patients who are ineffective or have poor treatment effects with traditional antipsychotic drugs, switching to this product may be effective. This product is also used to treat excitement, agitation, hallucinations and delusions in mania or other psychotic disorders. Because it causes neutropenia, it is generally not suitable as the first choice drug.

Oral administration starts with a small dose, the first dose is 25 mg (1 tablet) at a time, 2 to 3 times a day, and gradually increases slowly to the commonly used therapeutic dose of 200 to 400 mg a day (8 to 16 tablets), and the highest dose can reach 600 mg a day (24 tablets). The maintenance dose is 100 to 200 mg a day (4 to 8 tablets).

1. Strong sedative effect and more anticholinergic adverse reactions, common ones include dizziness, weakness, drowsiness, sweating, salivation, nausea, vomiting, dry mouth, constipation, postural hypotension, and tachycardia. 2. Common increased appetite and weight gain. 3. Can cause abnormal changes in electrocardiogram. Can cause changes in electroencephalogram or epileptic seizures. 4. Can also cause increased blood sugar. 5. Serious adverse reactions include agranulocytosis and secondary infection.

It is contraindicated for patients with severe heart, liver, or kidney disease, coma, delirium, hypotension, epilepsy, glaucoma, bone marrow suppression, or leukopenia. It is contraindicated for patients who are allergic to this product.

1. This product combined with ethanol or other central nervous system depressants may increase the central inhibitory effect. 2. This product combined with antihypertensive drugs may increase the risk of orthostatic hypotension. 3. This product combined with anticholinergic drugs may increase the anticholinergic effect. 4. This product combined with digoxin, heparin, phenytoin, and warfarin may aggravate the bone marrow suppression effect. 5. This product combined with lithium carbonate may increase the risk of convulsions, malignant syndrome, mental confusion and dystonia. 6. This product combined with antidepressants such as fluvoxamine, fluoxetine, paroxetine, and sertraline may increase the plasma levels of clozapine and norclozapine. 7n

Keep away from light and store in sealed container.

25 mg

Guangdong Heping Pharmaceutical Co., Ltd.

• Founded in:

  2002-09-10

• Address:

  No. 21 Shanhu Road, Heping County, Guangdong

• Tax NO.:

  91441624742971842K

• Registered Funds:

  17.5 million yuan

• Email:

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