Ramipril Tablets

Ramipril is a prodrug that is absorbed through the gastrointestinal tract and hydrolyzed in the liver into an active angiotensin converting enzyme (ACE) inhibitor, ramiprilat, to exert its effect. Taking ramipril can lead to an increase in plasma renin activity and a decrease in plasma concentrations of angiotensin II and aldosterone. Because of the reduction of angiotensin II, ACE inhibitors can lead to peripheral vasodilation and a decrease in vascular resistance, thereby producing a beneficial hemodynamic effect.

Ramipril. Chemical name: (2s, 3as, 6as)-1-{(s)-2-{[(s)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl}-octahydrocyclopenta[b]pyrrole-2-carboxylic acid.

This product is white or off-white tablets.

Hypertension. Congestive heart failure. Symptoms of congestive heart failure that occur within the first few days after an acute myocardial infarction.

For hypertension, start with 2.5 mgqd. Depending on the patient's response, if necessary, double the dose after an interval of 2-3 weeks. The general maintenance dose is 2.5-5 mg, and the maximum dose is 10 mg/day. For patients with renal insufficiency (creatinine clearance is 50-20 ml/min): the initial dose is usually 1.25 mgqd, and the maximum dose is 5 mg/day. The initial dose for congestive heart failure is 1.25 mgqd. Depending on the patient's response, the dose can be doubled after an interval of 1-2 weeks. If a daily dose of 2.5 mg or more is required, it can be taken in 2 doses. The maximum dose is 10 mg/day. The initial dose after myocardial infarction is 2.5 mgbid. If the patient cannot tolerate this initial dose, 1.25 mg can be taken bid for 2 consecutive days. The maximum dose is 10 mg/day.

Dizziness may occur, accompanied by inattention, fatigue, weakness, liver and kidney damage. Redness of the skin with burning sensation, itching, urticaria, other skin or mucous membrane rashes, conjunctivitis, sometimes a lot of hair loss, Raynaud's phenomenon may occur suddenly or aggravate, and rarely angioedema. Patients may have an irritating dry cough. Gastrointestinal adverse reactions, such as thirst, stomatitis, constipation, diarrhea, nausea and vomiting, stomach pain, upper abdominal discomfort. Blood picture may change.

Patients with a history of angioedema, patients with bilateral renal artery stenosis or single kidney with renal artery stenosis, patients with reduced left ventricular blood input or output, hypotension or unstable circulatory status, and pregnant and lactating women.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not for use by pregnant and lactating women. Precautions for the elderly: Not yet clear.

When used with antidiabetic drugs (such as insulin and sulfonylurea derivatives), attention should be paid to the possibility of excessive reduction of blood sugar. When used with potassium salts, potassium-sparing diuretics or heparin, serum potassium concentration may increase. Do not take it with potassium salts at the same time. ACE inhibitors will reduce the excretion of lithium salts and may cause an increase in serum lithium concentration. When used with other anti-inflammatory analgesics, the antihypertensive effect of this drug may be weakened and may lead to the occurrence of acute renal failure. This drug may enhance the effect of alcohol.

Sealed, protected from light, and stored below 30°C.

5mg

24 months

Kun Shan Rotam Reddy Pharmaceutical Co., Ltd.

• Founded in:

  1993-12-31

• Address:

  No. 2158 Huangpujiang Middle Road, Kunshan Development Zone, Jiangsu Province

• Tax NO.:

  91320583608278334C

• Registered Funds:

  $25,416,780

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