Sulindac Tablets

This product is a prodrug with minimal activity. After oral absorption, it metabolizes into sulfide in the body and has obvious anti-inflammatory and analgesic effects. Sulfide is a selective cyclooxygenase inhibitor that can reduce the synthesis of prostaglandins. Its effect is 500 times stronger than that of sulindac itself, but it has little effect on the synthesis of physiological prostaglandins in the kidneys. Because it passes through the gastrointestinal tract in an inactive form, it has little irritation to the gastrointestinal tract and has little effect on renal blood flow and renal function. This product can also inhibit the release of 5-hydroxytryptamine, inhibit collagen-induced platelet aggregation, and prolong bleeding time.

The main ingredients and chemical names of this product are: The main ingredient is sulindac, and its chemical name is (Z)-5-fluoro-2-methyl-1-[(4-methylsulfinylphenyl)methylene]-1H-indene-3-acetic acid.

The chemical name of this drug is cis-5-fluoro-2-methyl-1-[P-(methylsulfonyl)methylene]indene-3-acetic acid. The molecular formula is C20H17FO5S and the molecular weight is 356.42.

Suitable for rheumatoid arthritis and degenerative joint disease.

1Usual dosage for adults: oral anti-rheumatic medication 0.2g once, once in the morning and once in the evening; analgesic 0.2g for the first time, repeat after 8 hours; Common dosage for children over 22 years old: 2.25mg/kg once according to body weight, twice a day, daily dose should not exceed 6mg/kg.

(1) Common adverse reactions are gastrointestinal reactions, including upper abdominal pain, abdominal distension, indigestion, nausea, diarrhea, constipation, poor appetite, etc., and peptic ulcers are rare. (2) Central nervous system symptoms generally rarely occur, mainly dizziness, headache, drowsiness, and insomnia. (3) Bone marrow suppression, acute renal failure, heart failure, aseptic meningitis, liver damage, and Stevens-Johnson syndrome are rare. (4) Others: Occasionally, rashes, itching, irritability, depression, etc.

(1) Patients who are allergic to this product or other nonsteroidal anti-inflammatory drugs are contraindicated. (2) Patients with active peptic ulcers or a history of ulcer bleeding or perforation are contraindicated.

(1) When taken simultaneously with the anticoagulant warfarin, the prothrombin time may be prolonged. (2) When taken simultaneously with hypoglycemic drugs (such as tolbutamide), fasting blood sugar may be significantly reduced. (3) When taken simultaneously with aspirin, the activity of this drug may be reduced, thereby reducing the efficacy of this product and possibly causing peripheral neuropathy.

Keep away from light and store in sealed container.

0.1 g

48 months

Qingdao Guoxin Pharmaceutical Co., Ltd.

• Founded in:

  1994-11-24

• Address:

  No. 3601, Tuanjie Road, Qingdao Economic and Technological Development Zone

• Tax NO.:

  91370211614316886Y

• Registered Funds:

  62.748 million yuan

• Email:

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