Tranexamic Acid for Injection

Pharmacological action: Fibrinolysis is related to the body's fibrinolysis and increased vascular permeability under physiological or pathological conditions. It is also related to the body's reaction to fibrinolysis, the occurrence, development and cure of various bleeding symptoms and allergic reactions. This product can inhibit the action of this plasmin, and show hemostatic, anti-allergic and anti-inflammatory effects. 1. Anti-plasmin effect. Tranexamic acid can strongly adsorb to the lysine binding site (LBS) of the fibrin affinity site on plasmin and plasminogen, inhibiting the binding of plasmin and plasminogen to fibrin, thereby strongly inhibiting the fibrinolysis caused by plasmin; in addition, in the presence of anti-plasmins such as macroglobulins in serum, the anti-fibrinolytic effect of tranexamic acid is more obvious.

E-tranexamic acid

This product is white or off-white loose body.

This product is mainly used for various bleeding caused by acute or chronic, localized or systemic primary hyperfibrinolysis. This product is generally not used for secondary hyperfibrinolytic state caused by disseminated intravascular coagulation before heparinization. This product is also suitable for: 1. Traumatic or surgical bleeding in organs rich in plasminogen activators such as the prostate, urethra, lungs, brain, uterus, adrenal glands, and thyroid glands. 2. Used as an antagonist of tissue plasminogen activator (t-PA), streptokinase, and urokinase. 3. Fibrinolytic bleeding caused by artificial abortion, early placental abruption, stillbirth, and amniotic fluid embolism. 4. Excessive menstruation, hyphema, and severe epistaxis caused by pathologically increased local fibrinolysis in the uterine cavity. 5. Mild bleeding caused by rupture of central aneurysm, such as subarachnoid hemorrhage and intracranial aneurysm bleeding, this product is better than other antifibrinolytic drugs in stopping bleeding, but attention must be paid to the risk of concurrent cerebral edema or cerebral infarction. As for patients with severe conditions and surgical indications, this product can only be used as an auxiliary drug. 6. Treatment of hereditary angioedema can reduce the frequency and severity of its attacks. 7. This drug can be used in combination with hemophilia patients with active bleeding. 8. Prevent or reduce bleeding after tooth extraction or oral surgery in hemophilia patients with factor VIII or factor IX deficiency. 9. Severe bleeding caused by excessive thrombolysis.

Intravenous drip: Generally, adults take 0.25-0.5g at a time, and 1-2g per day if necessary, divided into 1-2 doses. The dose can be appropriately increased or decreased according to age and symptoms, or as directed by the doctor. To prevent bleeding before and after surgery, the above dose can be used as a reference. To treat bleeding caused by primary fibrinolysis. The dose can be increased as appropriate.

This product has fewer adverse reactions than 6-aminocaproic acid. Occasionally, there are cases of intracranial thrombosis and bleeding caused by drug overdose. There are also diarrhea, nausea and vomiting. Less common are menstrual discomfort (caused by blood coagulation during menstruation). Since this product can enter the cerebrospinal fluid, there may be central nervous system symptoms such as blurred vision, headache, dizziness, fatigue, etc. after injection, especially related to the injection speed, but it is rare. Those who must continue to use this product for a long time should undergo ophthalmic examination and monitoring (such as vision test, vision, visual field and fundus). Serious adverse reactions: According to reports, there are no reports of shock, so it should be closely observed. Once it occurs, the drug should be stopped immediately and symptomatic treatment should be given.

It is contraindicated for those who are allergic to any ingredient in this product.

Precautions for children: This experiment has not been conducted and there is no reliable reference. Precautions for pregnancy and lactation: This experiment has not been conducted and there is no reliable reference. Precautions for the elderly: Generally, elderly patients should reduce the dosage due to the decline of physiological functions, or follow the doctor's advice.

1. It is incompatible with thrombolytic agents such as penicillin or urokinase. 2. When used in combination with oral contraceptives, estrogen or prothrombin complex concentrates, there is an increased risk of thrombosis.

Store in a dark, dry place

0.4g

24 months

Zhejiang Jinhua Conba BIO-PHARM. Co., Ltd.

• Founded in:

  2000-05-26

• Address:

  No. 288, Jinqu Road, Jinhua City, Zhejiang Province

• Tax NO.:

  913307011472897859

• Registered Funds:

  520 million yuan

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