Co-sulfamethoxazole Tablets

This product is a compound preparation, each tablet contains 0.08g of trimethoprim and 0.4g of sulfamethoxazole.

This product is white tablets.

1. The usual dose for adults to treat bacterial infections is 160 mg of trimethoprim and 800 mg of sulfamethoxazole, taken once every 12 hours. For the treatment of Pneumocystis carinii pneumonia, take 3.75-5 mg/kg of trimethoprim and 18.75-25 mg/kg of sulfamethoxazole once, once every 6 hours. Preventive medication for adults: initially give 160 mg of trimethoprim and 800 mg of sulfamethoxazole twice a day, followed by the same dose once a day, or 3 times a week. 2. The usual dose for children is contraindicated for infants under 2 months old. For the treatment of bacterial infections, infants and young children aged 2 months and weighing less than 40 kg can take SMZ 20-30 mg/kg and TMP 4-6 mg/kg orally according to body weight once every 12 hours; the dose for children weighing ≥40 kg is the same as the usual dose for adults.

1. Allergic reactions are common and may manifest as drug eruptions. In severe cases, exudative erythema multiforme, exfoliative dermatitis, and bullous epidermolysis atrophic dermatitis may occur. There are also serum sickness-like reactions such as photosensitivity reactions, drug fever, joint and muscle pain, and fever. Anaphylactic shock is occasionally seen. 2. Neutropenia or deficiency, thrombocytopenia, and aplastic anemia. Patients may present with sore throat, fever, pallor, and bleeding tendency. 3. Hemolytic anemia and hemoglobinuria. This is prone to occur in patients who lack glucose-6-phosphate dehydrogenase after using sulfonamides, and is more common in newborns and children than in adults. 4. Hyperbilirubinemia and neonatal kernicterus. Because this product competes with bilirubin for protein binding sites, it can cause an increase in free bilirubin. Newborns have imperfect liver function and are sensitive to bilirubin.

1. Patients who are allergic to SMZ and TMP are prohibited from using this product. 2. Since this product blocks the metabolism of folic acid and aggravates the folate deficiency in patients with megaloblastic anemia, patients with this disease are prohibited from using this product. 3. Pregnant and lactating women are prohibited from using this product. 4. Infants under 2 months old are prohibited from using this product. 5. Patients with severe liver and kidney damage are prohibited from using this product.

Precautions for children: Since this product can compete with bilirubin for binding sites on plasma proteins, and the acetyltransferase system of newborns is not fully developed, the increased free blood concentration of sulfonamide can increase the risk of kernicterus. Therefore, the use of this type of drug in newborns and infants under 2 months old is contraindicated. Children are in the growth and development period, and their liver and kidney functions are not yet perfect, so the dosage should be reduced as appropriate. Precautions for pregnancy and lactation: It is not clear yet. Precautions for the elderly: Elderly patients have an increased chance of serious adverse reactions when using this product, such as severe skin allergic reactions such as rash, and blood system abnormalities such as bone marrow suppression, leukopenia and thrombocytopenia. It is more likely to occur when using diuretics at the same time. Therefore, elderly patients should avoid using it, and when there is an indication, the pros and cons should be weighed before deciding.

Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.

seal.

0.1g*12s

24 months

Jiuhua Huayuan Pharmaceutical (Guilin) Co., Ltd.

• Founded in:

  1999-06-23

• Address:

  The third floor of the No. 2 standard factory building in Yangtang Industrial Park, Lingui Town, Lingui District, Guilin City

• Tax NO.:

  914502008986046438

• Registered Funds:

  5.1 million yuan

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