Carbamazepine Tablets

This product is an anticonvulsant and antiepileptic drug. The pharmacological effects of carbamazepine are anticonvulsant, antiepileptic, anti-neuropathic pain, anti-manic-depressive, improvement of symptoms of certain mental illnesses, and anti-central diabetes insipidus. The mechanisms of these effects may be: 1. Use-dependent blocking of various Na channels of excitable cell membranes, so it can significantly inhibit the occurrence and spread of abnormal high-frequency discharges; 2. Inhibit T-type calcium channels; 3. Enhance the activity of central noradrenergic nerves; 4. Promote the secretion of antidiuretic hormone (ADH) or increase the sensitivity of effectors to ADH.

Carbamazepine.

This product is white.

1. Epilepsy: partial seizures: complex partial seizures, simple partial seizures and secondary generalized seizures. Generalized seizures: tonic, clonic, tonic-clonic seizures. 2. Attacks of trigeminal neuralgia and glossopharyngeal neuralgia. It is also used as a long-term preventive medication after the relief of trigeminal neuralgia. It can also be used for tabes dorsalis and multiple sclerosis, diabetic peripheral neuropathy, pain in the affected limbs, post-traumatic neuralgia and post-herpetic neuralgia. 3. Prevention or treatment of manic-depression; manic-depression that is ineffective or intolerant to lithium, antipsychotics and antidepressants can be used alone or in combination with lithium salts and other antidepressants. 4. Central partial diabetes insipidus can be used alone or in combination with chlorpropamide or clofibrate. 5. Withdrawal syndrome of alcoholism.

1. Adults: (1) Anticonvulsant, initial dose 100-200 mg each time, 1-2 times a day, gradually increase the dose until the best effect. (2) Analgesia, start with 0.1 g once, 2 times a day; increase 0.1-0.2 g every other day after the second day until the pain is relieved, maintenance dose 0.4-0.8 g daily, divided into several doses; the maximum daily dose should not exceed 1.2 g. (3) Diabetes insipidus, when used alone, 0.3-0.6 g per day; if used in combination with other antidiuretics, 0.2-0.4 g per day, divided into 3 doses. (4) Anti-mania or antipsychotic, start with 0.2-0.4 g per day, gradually increase to a maximum of 1.6 g per week, divided into 3-4 doses. Daily limit: 12-15 years old, no more than 1 g; 15 years old and above, no more than 1.2 g; a few people use up to 1.6 g. Usually the adult limit is 1.2 g, 12-15 years old, no more than 1 g per day, a few people need to use up to 1.6 g. For analgesia, the daily dosage should not exceed 1.2g. 2. For children, 10-20mg/kg. The blood concentration should be maintained between 4-12ug/ml.

1. The most common adverse reactions are reactions of the central nervous system, manifested as dizziness, ataxia, drowsiness and fatigue. 2. Water retention and hyponatremia (or water intoxication) caused by stimulating the secretion of antidiuretic hormone, the incidence rate is about 10% to 15%. 3. Less common adverse reactions include allergic reactions, Stevens-Johnson syndrome or toxic epidermal necrolysis, rash, urticaria, itching; behavioral disorders in children, severe diarrhea, lupus erythematosus-like syndrome (urticaria, itching, rash, fever, sore throat, bone or joint pain, fatigue). 4. Rare adverse reactions include glandular disease, arrhythmia or atrioventricular block (especially for the elderly), bone marrow suppression, central nervous system poisoning (language difficulties, mental restlessness, tinnitus, tremor, hallucinations), allergic hepatitis, hypocalcemia, direct impact on bone metabolism leading to osteoporosis, kidney poisoning, peripheral neuritis, acute urinary porphyria, thromboangiitis, allergic pneumonia, acute intermittent porphyria, and hypothyroidism. There was a case of myoclonic epilepsy with aseptic meningitis, which caused recurrence of meningitis after receiving this product. Occasionally, granulocytopenia, reversible thrombocytopenia, aplastic anemia, and toxic hepatitis are seen.

It is contraindicated for patients who are allergic to carbamazepine, or have a history of atrioventricular block, severe serum iron abnormalities, bone marrow suppression, or severe liver dysfunction.

Precautions for children: This product can be used for children of all ages, please refer to [Usage and Dosage] for details. Precautions for pregnancy and lactation: This product can pass through the placenta, and it is not clear whether it is teratogenic. It should be used with caution in early pregnancy; this product can be secreted into breast milk, with a blood concentration of about 60%, and it should not be used by lactating women. Precautions for the elderly: Elderly patients are often sensitive to this product, which can often cause cognitive dysfunction, agitation, restlessness, anxiety, mental confusion, atrioventricular block or bradycardia, and can also cause aplastic anemia.

1. When used in combination with acetaminophen, especially in a single overdose or long-term large doses, the risk of liver poisoning increases, which may reduce the efficacy of the latter. 2. When used in combination with coumarin anticoagulants, due to the positive induction of liver enzymes by this product, the blood concentration of anticoagulants is reduced, the half-life is shortened, and the anticoagulant effect is weakened. The prothrombin time should be measured and the dosage adjusted. 3. When used in combination with carbonic anhydrase inhibitors, the risk of osteoporosis increases. 4. Due to the liver enzyme induction effect of this product, when used in combination with chlorpropamide, clofibrate (clofibrate), desmopressin, lypressin, vasopressin, vasopressin, etc., the antidiuretic effect can be enhanced, and the dosage of each combined drug needs to be reduced. 5. When used in combination with contraceptives containing estrogen, cyclosporine, digitalis (except possibly digoxin), estrogen, levothyroxine or quinidine, the effects of these drugs will be reduced due to the induction of liver enzymes by carbamazepine. The dosage should be adjusted and oral contraceptives containing only progestin (progesterone) should be used instead. Heavy vaginal bleeding may occur when used in combination with oral contraceptives. 6. When used in combination with doxycycline (doxycycline), the latter's blood concentration may be reduced. If necessary, the dosage needs to be adjusted. 7. Erythromycin, troleandomycin and detropropoxyphene can inhibit the metabolism of carbamazepine, causing the latter's blood concentration to increase and toxic reactions to occur. 8. Haloperidol, loxapine, maprotiline, thioxanthenes or tricyclic antidepressants can enhance the metabolism of carbamazepine, causing the latter's blood concentration to increase and toxic reactions to occur. 9. Lithium salts can reduce the antidiuretic effect of carbamazepine. 10. When used in combination with monoamine oxidase (MAO) inhibitors, it may cause high fever or (and) hypertensive crisis, severe convulsions or even death. The two drugs should be used at least 14 days apart. When carbamazepine is used as an anticonvulsant, MAO inhibitors can change the type of epileptic seizure. 11. Carbamazepine can reduce the absorption of nomifensine and accelerate its elimination. 12. Phenobarbital and phenytoin accelerate the metabolism of carbamazepine and can reduce the t1/2 of carbamazepine to 9-10 hours. 13. Carbamazepine should be avoided in combination with monoamine oxidase inhibitors. Before taking it, stop taking the MAO inhibitor for at least two weeks, and if the clinical situation permits, the MAO inhibitor can be stopped for longer.

Keep away from light and store in sealed container.

0.1 g

36 months.