Sodium Chloride Injection

Sodium chloride is an electrolyte supplement. Sodium and chloride are important electrolytes in the body, mainly present in extracellular fluid, and play a very important role in maintaining normal blood and extracellular fluid volume and osmotic pressure. The normal serum sodium concentration is 135-145mmol/L, accounting for 92% of plasma cations and 90% of total osmotic pressure, so the plasma sodium content plays a decisive role in osmotic pressure. The normal serum chloride concentration is 98-106mmol/L. Sodium and chloride ions in the human body are mainly regulated by the hypothalamus, posterior pituitary and kidneys to maintain the stability of body fluid volume and osmotic pressure.

This product is an isotonic sterile aqueous solution of sodium chloride. The sodium chloride (NaCl) content should be 0.850% to 0.950% (g/ml).

Water loss due to various reasons includes hypotonic, isotonic and hypertonic water loss; hypertonic non-ketotic diabetic coma can be corrected by using isotonic or hypotonic sodium chloride; hypochloremic metabolic alkalosis; external use of normal saline to wash eyes and wounds, etc.; also used for water bag induction in obstetrics

1. Hypertonic dehydration: When patients have hypertonic dehydration, the osmotic concentration of brain cells and cerebrospinal fluid increases. If the treatment causes the sodium concentration and osmotic concentration of plasma and extracellular fluid to drop too quickly, it may cause cerebral edema. Therefore, it is generally believed that the plasma sodium concentration should not drop by more than 0.5mmol/L per hour within 48 hours after the start of treatment. If the patient is in shock, sodium chloride injection should be given first and colloid should be supplemented as appropriate. When the shock is corrected, when the blood sodium is 155mmol/L and the plasma osmotic concentration is 350mOsm/L, 0.6% hypotonic sodium chloride injection can be given. When the plasma osmotic concentration reaches 330mOsm/L, 0.9% sodium chloride injection can be used instead. The total amount of fluid replacement is calculated according to the following formula as a reference: The required amount of fluid replacement (L) = [blood sodium concentration (mmol/L) - 142] & times ;0.6×body weight (Kg)÷blood sodium concentration (mmol/L)Usually, half of the dose is replenished on the first day, and the rest is replenished within the next 2-3 days and adjusted according to the cardiopulmonary and renal function. 2 Isotonic dehydration: In principle, isotonic solution such as 0.9% sodium chloride injection or compound sodium chloride injection is given. However, the chloride concentration of the above solution is significantly higher than that of plasma. Large-scale use alone can cause hyperchloremia. Therefore, 0.9% sodium chloride injection and 1.25% sodium bicarbonate or 1.86% (1/6M) sodium lactate can be prepared in a ratio of 7:3 and then replenished. The chloride concentration of the latter is 107mmol/L and can correct metabolic acidosis. The replenishment amount can be calculated according to body weight or hematocrit as a reference. ① Calculated according to body weight: Fluid replacement amount (L) = (body weight) ② Calculated by hematocrit: Fluid replacement (L) = (actual hematocrit - normal hematocrit) x body weight (kg) x 0.2/normal hematocrit. Normal hematocrit is 48% for males and 42% for females. 3 Hypotonic dehydration: In severe hypotonic dehydration, the solutes in brain cells decrease to maintain cell volume. If the treatment causes the plasma and extracellular fluid sodium concentrations and osmotic concentrations to rise rapidly, brain cell damage may occur. It is generally believed that when blood sodium is lower than 120mmol/L, treatment should be used to increase blood sodium by 0.5mmol/L per hour and not more than 1.5mmol/L per hour. When blood sodium is lower than 120mmol/L or occurs In case of central nervous system symptoms, 3%-5% sodium chloride injection can be given by slow drip. Generally, it is required to increase the blood sodium concentration to above 120mmol/L within 6 hours. The amount of sodium supplement (mmol) = [142-actual blood sodium concentration (mmol/L)] x body weight (kg) x 0.2. When the blood sodium rises to above 120-125mmol/L, isotonic solution can be used instead, or hypertonic glucose injection or 10% sodium chloride injection can be added to the isotonic solution as appropriate. 4. Hypochloremic alkalosis: 0.9% sodium chloride injection or compound sodium chloride injection (Ringer's solution) is given, 500-1000ml, and the dosage is determined according to the alkalosis situation. 5. For external use, wash the wound with physiological sodium chloride solution and rinse the eyes.

1. Too much or too fast infusion can cause water and sodium retention, resulting in edema, increased blood pressure, increased heart rate, chest tightness, dyspnea and even acute left heart failure. 2. Too much or too fast administration of hypotonic sodium chloride can cause hemolysis, cerebral edema, etc.

Contraindicated in pregnancy induced hypertension

When used as a drug solvent or diluent, attention should be paid to the incompatibility between drugs

Keep tightly closed.

250ml:2.25g

Guangdong Otsuka Pharmaceutical Co., Ltd.

• Founded in:

  1993-06-01

• Address:

  Foshan Shunde District Ronggui Street High-tech Industrial Development Park

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  91440606617475057M

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