Azithromycin Granules

Azithromycin is a 15-membered macrolide antibiotic. In vitro tests have shown that azithromycin has antibacterial effects on a variety of common clinical pathogens, including: Gram-positive aerobic bacteria: Staphylococcus aureus, Streptococcus pyogenes (group A beta; hemolytic streptococci), pneumonia (streptococci), hemolytic streptococci (grass-green streptococci) and other streptococci. Diphtheria (rod-shaped) bacilli. This product shows cross-resistance to erythromycin-resistant Gram-positive bacteria, including faecal streptococci (enterococci) and various methicillin-resistant Staphylococcus aureus strains. Gram-negative aerobic bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Acinetobacter, Yersinia, Legionella pneumophila, Bordetella pertussis, Bordetella parapertussis, Shigella, Pasteurella, Vibrio cholerae, parahaemolytic bacilli, Shigella pyriformis. This product is effective against the following Activity against gram-negative bacteria depends on the strain and requires sensitivity testing: Escherichia coli, Salmonella typhi, Enterobacter, Hydrophila, Klebsiella, Anaerobic bacteria: Bacteroides fragilis, Bacillus perfringens, Peptostreptococcus, Fusobacterium necroticum, Propionibacterium acnes, Sexually transmitted disease organisms: Treponema pallidum, Neisseria gonorrhoeae, Haemophilus dukei, Other organisms: Including Borrelia tenuissima (Lyme disease), Mycoplasma pneumoniae, Mycoplasma hominis, Ureaplasma urealyticum, Chlamydia trachomatis, Pneumocystis carinii, Mycobacterium avium, Campylobacter, Listeria monocytogenes The following gram-negative bacteria are usually resistant: Proteus, Serratia, Morganella, Pseudomonas The mechanism of action is the same as erythromycin, mainly binding to the 50S subunit of the bacterial ribosome, inhibiting RNA-dependent protein synthesis

Azithromycin molecular formula: C38H72N2O12 molecular weight: 749

This product is white or off-white granules.

1. Acute pharyngitis and acute tonsillitis caused by Streptococcus pyogenes; 2. Sinusitis, otitis media, acute bronchitis and acute exacerbation of chronic bronchitis caused by sensitive bacteria; 3. Pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae and Mycoplasma pneumoniae; 4. Urethritis and cervicitis caused by Chlamydia trachomatis and non-multidrug-resistant Neisseria gonorrhoeae; 5. Skin and soft tissue infections caused by sensitive bacteria.

Pour this product into a cup, add appropriate amount of cold boiled water to dissolve, shake well and take orally 1 hour before or 2 hours after meals. Adult dosage: 1. For sexually transmitted diseases caused by Chlamydia trachomatis or sensitive Neisseria gonorrhoeae, only 1.0g of this product is needed for a single oral dose. 2. For the treatment of other infections: 0.5g on the first day, 0.25g on the second to fifth days, or 0.5g on the first day for 3 consecutive days. Pediatric dosage: 1. For the treatment of otitis media and pneumonia, take 10mg/kg of body weight on the first day (maximum daily dose is not More than 0.5g) On the 2nd to 5th day, take 5mg/kg of body weight once a day (maximum daily dose not exceeding 0.25g) or administer as follows: Body weight (kg) First day 2nd to 5th day 15-250.2g once a day 0.1g once a day 26-350.3g once a day 0.15g once a day 36-450.4g once a day 0.2g once a day 2. Treatment of pharyngitis and tonsillitis in children Take 12mg/kg of body weight once a day (maximum daily dose not exceeding 0.5g) for 5 consecutive days

Gastrointestinal reactions such as abdominal pain, diarrhea (loose stools), upper abdominal discomfort (pain or cramps), nausea and vomiting may occur after taking the medicine. The incidence is significantly lower than that of erythromycin. Mild to moderate abdominal distension, dizziness, headache, fever, rash, joint pain and other allergic reactions may occur occasionally. Anaphylactic shock and angioneurotic edema. Cholestatic jaundice is extremely rare. A small number of patients may experience transient neutropenia and elevated serum aminotransferase.

Contraindicated in patients allergic to azithromycin, erythromycin or any other macrolide drugs

Precautions for children: Regardless of the type of infection, the recommended total dose of azithromycin in children is no more than 1500 mg. Azithromycin dry suspension is used for children weighing more than 45 kg, and the usage and dosage are the same as adults. The efficacy and safety of treating otitis media, community-acquired pneumonia in children under 6 months old, and pharyngitis or tonsillitis in children under 2 years old have not yet been determined. Precautions for pregnancy and lactation: Animal experiments have shown that this product has no effect on the fetus, but there is still a lack of experience in its use in pregnant women, so the pros and cons must be fully weighed when used in pregnant women. There is no data showing whether this product can be secreted into breast milk, so the use of lactating women must be considered with caution. Precautions for the elderly: This experiment has not been conducted and there are no reliable references.

1. It is not advisable to take it at the same time with antacids containing aluminum or magnesium, as the latter can reduce the peak blood concentration of this product. If it must be taken together, this product should be given 1 hour before or 2 hours after taking the above drugs. 2. When used together with theophylline, the concentration of the latter in plasma can be increased, and attention should be paid to detecting the plasma theophylline level. 3. When used together with warfarin, attention should be paid to checking the prothrombin time. 4. When used together with the following drugs, it is recommended to closely observe the patient: Digoxin increases the digoxin level; Ergotamine or dihydroergotamine; The symptoms of acute ergot toxicity are severe peripheral vasospasm and dysesthesia (pain when touching objects); Triazolam enhances the pharmacological effect of triazolam by reducing its degradation; Metabolites of the cytochrome P450 system increase the levels of carbamazepine, terfenadine, cyclosporine, cyclohexylbarbital, and phenytoin in serum. 5. When used together with rifabutin, the latter's toxicity will be increased.

Sealed, store in a dry place.

0.1g

24 months

Dajiaweikang Biopharmaceutical Co., Ltd.

• Founded in:

  2022-06-15

• Address:

  No. 9, Hantai Road, Hunan Hanshou High-tech Industrial Park

• Tax NO.:

  91430722MABNWDNW6X

• Registered Funds:

  213.15 million yuan

• Email:

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