Pralidoxime Iodide Injection

This product is an oxime compound. Its quaternary ammonium group can tend to the cationic site of the inactive phosphorylated cholinesterase that has been combined with the organophosphorus insecticide. Its nucleophilic group can directly combine with the phosphorylated group of cholinesterase and then detach from the cholinesterase together, so that the cholinesterase can be restored to its original state. It regains its vitality. The effect of rejuvenating the aged cholinesterase that has been inhibited by organophosphorus insecticides for more than 36 hours is very poor. It has no resurrection effect on the cholinesterase inhibited by chronic organic insecticide poisoning. This product has a significant effect on the nicotinic symptoms caused by organophosphorus insecticides, but a weak effect on muscarinic symptoms, and no significant effect on central nervous system symptoms.

The main ingredients of this product and its chemical name: pralidoxime iodide, chemical name is 1-methylpyridine-2-aldehyde oxime iodide. Its molecular formula: C7H9N2OI, molecular weight: 264.07.

This product is a colorless or almost colorless clear liquid.

It has different degrees of resurrection effect on the activity of cholinesterase inhibited by acute organophosphate insecticides, and is used to rescue poisoning by various organophosphate insecticides. However, it has poor effect on poisoning by malathion, trichlorfon, dichlorvos, dimethoate, dimefox, mipafox and schradan, etc.; it has no resurrection effect on cholinesterase inhibited by carbamate insecticides.

The usual dose for adults is 0.5 to 1 g for a single intravenous injection, which can be repeated if necessary.

After injection, it can cause nausea, vomiting, increased heart rate, temporary S-T segment depression and prolonged Q-T time on the electrocardiogram. Injection too quickly can cause dizziness, blurred vision, diplopia, and uncoordinated movements. Excessive doses can inhibit cholinesterase, inhibit breathing, and cause epileptic seizures. Bitter taste in the mouth and swelling of the parotid gland are related to iodine.

This product is contraindicated for patients who are allergic to iodine.

1. This product is a cholinesterase reactivator. It can indirectly reduce the accumulation of acetylcholine and has a significant effect on the neuromuscular junction of skeletal muscle. Atropine has a direct antagonistic effect on the accumulation of acetylcholine and has a stronger effect on the autonomic nerves. The combined use of the two drugs has a significant clinical effect. This product has an enhanced biological effect of atropine, so the dose of atropine should be reduced when the two drugs are used at the same time. The first dose of atropine is 2-4 mg for general poisoning, once every 10 minutes, and 4-6 mg for severe poisoning, every 5-10 minutes, intramuscular or intravenous injection until atropineization occurs. Atropineization should be maintained for 48 hours, and then the dose of atropine should be gradually reduced or the injection time should be extended. 2. This product is easily decomposed in alkaline solution and is forbidden to be compatible with alkaline drugs. 3. The first dose is 0.8 g for general poisoning patients and 1.6 g for severe patients. According to clinical symptoms and blood cholinesterase levels, the injection should be repeated once every 2-6 hours, or 100-300 mg per minute should be intravenously dripped for 2-3 times. In patients with severe and oral poisoning, treatment with this drug may need to be continued for several days.

Keep away from light and store in a sealed container.

20ml:0.5g

Shanghai Xudong Haipu Pharmaceutical Co., Ltd.

• Founded in:

  1993-01-06

• Address:

  No. 879, Jinhu Road, China (Shanghai) Pilot Free Trade Zone

• Tax NO.:

  91310115607203592Y

• Registered Funds:

  $9,478,623

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