Triamterene Tablets

This drug directly inhibits the Na+-K+ exchange in the distal tubules and collecting ducts of the kidney, thereby increasing the excretion of Na+, C1-, and water, and reducing the excretion of K+.

Main ingredient: triamterene Chemical name: 2,4,7-triamino-6-phenyl-pteridine. Molecular formula: C12H11N7 Molecular weight: 253.27

This product is a yellow tablet.

This product is mainly used to treat edema diseases, including congestive heart failure, ascites due to liver cirrhosis, nephrotic syndrome, etc. As well as water and sodium retention during adrenal glucocorticoid treatment, the main purpose is to correct the secondary aldosterone secretion increase in the above situation, and antagonize the potassium excretion effect of other diuretics. It can also be used to treat idiopathic edema.

1Usual oral dose for adults. Start with 25~100mg per day, divided into 2 doses. The dose can be reduced when used with other diuretics. It can be changed to alternate-day therapy during the maintenance phase. The maximum dose does not exceed 300mg per day. 2Usual oral dose for children. Start with 2~4mg/kg per day based on body weight or 120mg/m2 per body surface area, divided into 2 doses, daily or alternate-day therapy. Adjust the dose as appropriate later. The maximum dose does not exceed 6mg/kg or 300mg/m2 per day.

1. The most common one is hyperkalemia. 2. The less common ones are: ① Gastrointestinal reactions, such as nausea, vomiting, stomach cramps and diarrhea; ② Hyponatremia; ③ Dizziness, headache; ④ Photosensitivity. 3. The rare ones are: ① Allergies, such as rash, dyspnea; ② Blood system damage, such as granulocytopenia or even agranulocytosis, thrombocytopenic purpura, megaloblastic anemia (interference with folic acid metabolism); ③ Kidney stones. It has been reported that the incidence of kidney stones in long-term users of this drug is 1/1500. The mechanism may be that the concentration of this drug and its metabolites in urine is supersaturated, crystallizes and combines with protein matrix, thus forming kidney stones.

Contraindicated in case of hyperkalemia.

Precautions for children: This product has not been tested and there is no reliable reference. Precautions for pregnancy and lactation: 1. Animal experiments show that this drug can pass through the placenta, but the situation in humans is not clear. 2. Experiments in cows show that this drug can be secreted in breast milk, but the situation in humans is not clear. Precautions for the elderly: The elderly are more likely to develop hyperkalemia and renal damage when using this drug.

(1) Adrenal cortical hormones, especially those with strong mineralocorticoid effects, target=_blank adrenocorticotropic hormone can weaken the diuretic effect of this drug and antagonize its potassium-retaining effect. (2) target=_blank Estrogen can cause water and sodium retention, thereby weakening the diuretic effect of this drug. (3) Non-steroidal anti-inflammatory analgesics, especially indomethacin, can reduce the diuretic effect of this drug, and increase renal toxicity when used in combination. (4) Sympathomimetic drugs reduce the antihypertensive effect of this drug. (5) Dopamine enhances the diuretic effect of this drug. (6) When used in combination with drugs that cause a decrease in blood pressure, both the diuretic and antihypertensive effects are enhanced. (7) When used in combination with the following drugs, the chance of target=_blank hyperkalemia increases, such as potassium-containing drugs, stored blood (containing 30mmol/L potassium, and potassium up to 65mmol/L if stored for more than 10 days), angiotensin converting enzyme inhibitors, target=_blank angiotensin II receptor antagonists and target=_blank cyclosporine A. (8) When used in combination with glucose insulin solution, alkaline agents, and sodium-type potassium-lowering exchange resins, the chance of hyperkalemia decreases. (9) This drug prolongs the half-life of digoxin. (10) When used in combination with ammonium chloride, target=_blank metabolic acidosis is likely to occur. (11) When used in combination with nephrotoxic drugs, nephrotoxicity increases. (12) Sodium carbenoxolone and licorice preparations have aldosterone-like effects and can reduce the diuretic effect of this drug. (13) Because it can increase target=_blank blood uric acid, it can further increase target=_blank blood uric acid when used in combination with thiazide and loop diuretics, so it should be used in combination with drugs for the treatment of target=_blank gout. (14) It can increase blood sugar, so when used in combination with hypoglycemic drugs, the latter's dose should be appropriately increased.

Keep sealed.

50mg

24 months

Jilin Wantong Pharmaceutical Group Meihe Pharmaceutical Co., Ltd.

• Founded in:

  2001-10-18

• Address:

  No. 666, Wantong Road, Meihekou City, Jilin Province

• Tax NO.:

  91220501723125157E

• Registered Funds:

  66 million yuan

• Email:

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