Ursodeoxycholic acid tablets

Ursodeoxycholic acid accounts for a small part of human bile. After oral administration of ursodeoxycholic acid, the cholesterol saturation in bile is reduced by inhibiting the reabsorption of cholesterol in the intestine and reducing the secretion of cholesterol into bile. Cholesterol stones are gradually dissolved, probably due to the dispersion of cholesterol and the formation of liquid crystals. According to existing knowledge, the treatment of liver and cholestatic diseases with ursodeoxycholic acid capsules is mainly based on the relative replacement of lipophilic, detergent-like toxic bile acids by hydrophilic, cytoprotective and non-cytotoxic ursodeoxycholic acid, as well as the promotion of hepatocyte secretion and immunomodulation.

The main ingredient of this product is ursodeoxycholic acid. Its chemical name is 3alpha,7beta-dihydroxy-5beta-cholestane-24-acid.

Ursodeoxycholic acid is a white crystalline powder, odorless and bitter. It is almost insoluble in water, easily soluble in ethanol and glacial acetic acid, slightly soluble in imitation, and very slightly soluble in ether. This product is a white tablet.

This product is used for cholesterol gallstone formation and bile-deficient steatorrhea. It can also be used to prevent drug-induced stone formation and treat steatorrhea (after ileal resection).

Adult oral administration: 8-10 mg/kg daily, divided into two doses during the morning and evening meals. The shortest course of treatment is 6 months. If there is no improvement in ultrasound examination and cholecystography after 6 months, the drug can be discontinued; if the stones have partially dissolved, continue to take the drug until the stones are completely dissolved.

The toxicity and side effects of this product are less than those of chenodeoxycholic acid. It generally does not cause diarrhea. Other occasional adverse reactions include constipation, allergies, headaches, dizziness, pancreatitis, and tachycardia. During the treatment period, it may cause calcification of gallstones and soft stools.

Acute biliary infection, biliary obstruction, pregnant and lactating women.

Precautions for children: Not clear. Precautions for pregnancy and lactation: Contraindicated for pregnant and lactating women. Precautions for the elderly: Use with caution in elderly patients.

1. Contraceptive pills can increase bile saturation. When using this product for treatment, other birth control measures should be taken as much as possible to avoid affecting the efficacy. 2. Cholestyramine (Cholestyramine), colestipol (Colestipol) and aluminum-containing antacids can bind to CDCA and reduce its absorption, so they should not be used together.

Keep away from light and sealed

0.15g

24 months

Shanghai Sine Pharmaceutical Laboratories Co., Ltd.

• Founded in:

  1993-10-23

• Address:

  No. 905, Xinjinqiao Road, China (Shanghai) Pilot Free Trade Zone

• Tax NO.:

  91310000133742534B

• Registered Funds:

  1,191,611,312 yuan

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