Dipyridamole Tablets
Function and Efficacy
It has anti-thrombotic effect. Dipyridamole inhibits platelet aggregation, and high concentrations (50 mu; g/ml) can inhibit platelet release. The mechanism of action may be: 1. Inhibits the uptake of adenosine by erythrocytes, which is a platelet reaction inhibitor; 2. Inhibits phosphodiesterase, which increases cyclic adenosine monophosphate (cAMP) in platelets; 3. Inhibits the formation of thromboxane A2 (TXA2), which is a strong agonist of platelet activity; 4. Enhances endogenous PGI2. Dipyridamole has a vasodilatory effect. Dogs given 0.5~4.0 mg/kg of dipyridamole by duodenum produce dose-related decreases in systemic and coronary vascular resistance, lower systemic blood pressure, and increased coronary blood flow. It takes effect 24 minutes after administration and lasts for about 3 hours. Similar effects were observed after intravenous injection of 0.025~2.0 mg/kg.
Ingredients
Chemical name: (2,2prime;,2Prime;,2Prime;prime;-[4,8-dipiperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl]bis(nitrogen)-tetraethanol)
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| DipyridamoleIngredients |
It has anti-thrombotic effects. It inhibits platelet aggregation and release, which may be achieved through the following mechanisms: 1. Inhibits the uptake of adenosine by red blood cells; 2. Inhibits phosphodiesterase to increase cyclic adenosine monophosphate (cAMP) in platelets; 3. Inhibits the formation of thromboxane A2 (TXA2); 4. Enhances endogenous PGI2. In addition, it has a vasodilating effect, which can reduce systemic circulation and coronary vascular resistance and increase coronary blood flow. More |
58-32-2 | 35 |
Appearance
Film-coated tablets.
Indication
Used for thromboembolic diseases and ischemic heart disease.
Usage and Dosage
Oral administration: 25-50 mg each time, 3 times a day, before meals. Or as directed by a doctor.
Adverse Reactions
Adverse reactions are mild and short-lived at therapeutic doses, and most of the initial side effects disappear after long-term use. Common adverse reactions include dizziness, headache, vomiting, diarrhea, flushing, rash and itching, and rarely angina and liver dysfunction. Persistent or intolerable adverse reactions are rare and can be eliminated after discontinuation of the drug. In post-marketing experience reports, rare adverse reactions include laryngeal edema, fatigue, discomfort, myalgia, arthritis, nausea, dyspepsia, paresthesia, hepatitis, alopecia, cholelithiasis, palpitations and tachycardia.
Precautions
Not yet clear
Special Population Medication
Precautions for children: The safety and efficacy of the drug for children under 12 years old must be determined. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.
Drug Interactions
It has a synergistic effect with aspirin.
Storage
Keep in a light-proof and airtight container.
Packaging Specification
25mg
Validity Period
24 months.
Manufacturer
Yunpeng Pharmaceutical Group Co., Ltd.
-
Founded in:
1998-09-15 -
Address:
No. 19, Yunpeng Avenue, Pharmaceutical Industrial Park, Xiangfen County, Linfen City, Shanxi Province -
Tax NO.:
911410027136140375 -
Registered Funds:
200 million yuan -
Website:
-
Email: