Thiamine hydrochloride 67-03-8

Thiamine hydrochloride

Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-,chloride,hydrochloride (1:1:1);Thiamine,monohydrochloride;Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-,chloride,monohydrochloride;3-(4-Amino-2-methylpyrimidyl-5-methyl)-4-methyl-5,β-hydroxyethylthiazolium chloride hydrochloride;Aneurine hydrochloride;Apate drops;Beatine;Bedome;Begiolan;Benerva;Bequin;Berin;Betabion;Betalin S;Betaxin;Bethiazine;Beuion;Bevitine;Bewon;Biuno;Bivatin;Bivita;Clotiamina;Eskapen;Eskaphen;Lixa-Beta;Metabolin;Slowten;THD;Thiadoxine;Thiaminal;Thiamine chloride hydrochloride;Thiamine dichloride;Thiamine hydrochloride;Thiamin hydrochloride;Thiaminium chloride;Thiaminium chloride hydrochloride;Thiamol;Thiavit;Tiamidon;Tiaminal;Trophite;Vetalin S;Vinothiam;Vitamin B1 hydrochloride;Vitaneuron;Thiamine chloride;Thiamin chloride;Thiamin dichloride;Biamine;3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium hydrochloride chloride;63-66-1;70732-86-4;108631-50-1;2173536-98-4;2227489-38-3

67-03-8

C12H17N4OS.ClH.Cl

InChIKey=DPJRMOMPQZCRJU-UHFFFAOYSA-M

337.27

336.058

3851771

200-641-8

M572600E5P

36226

DTXSID0040622

C48025

Crystals from water

29362200

Bulk Drug Intermediates

104

-1.00510

White to almost white Crystalline Powder

1.3766 (rough estimate)

248 °C (decomp)

100ºC

H2O: 0.1 g/mL at 20 °C, clear, colorless

2-8°C

1.8X10-10 mm Hg at 25 deg C (est)

LD50 in mice (mg/kg): 89.2 i.v.; 8224 orally (Winter)

SLIGHT, CHARACTERISTIC

Monoclinic plates in rosette-like clusters. Slight thiazole odor; bitter taste; decomposes at 248 °C. One gram dissolves in approximately 1 mL water, 18 mL glycerol, 100 mL 95% alcohol, 315 mL absolute alcohol; more soluble in methanol. Soluble in propylene glycol. Practically insoluble in ether, benzene, hexane, chloroform. pH of 1% wt/vol solution in water 3.13; pH of 0.1% wt/vol solution in water 3.58. On exposure to air of average humidity, the vitamin absorbs an amount of water corresponding to nearly one mole, forming a hydrate.|HYGROSCOPIC; NUT-LIKE ODOR /HYDROCHLORIDE/|READILY SPLIT BY SULFITE INTO ITS PYRIMIDINE & THIAZOLE CONSTITUENTS|Crystals. MP: 196-200 °C, decomposes; practically nonhygroscopic; pKa = 4.9. Solubility in water (g/100 mL): 2.7 (25 °C); approximately 30 (100 °C). pH of 2% aqueous solution 6.5 to 7.1, more stable than the hydrochloride; suitable for enrichment of flours and feeds, multivitamin preparations /Mononitrate/|SMALL WHITE CRYSTALS OR CRYSTALLINE POWDER /HYDROCHLORIDE/|Thiamine hydrochloride in the dry state is stable. Acidic solutions having a pH below 5.5 preferably from 5.0 to 3.5 are also relatively stable. Alkalies destroy it. It is precipitated from solution by several of the alkaloidal reagents such as mercuric chloride, iodine, picric acid, tannin, and Mayer's reagent. It is sensitive to both oxidizing and reducing agents. /Hydrochloride/|For more Other Experimental Properties (Complete) data for Vitamin B1 (6 total), please visit the HSDB record page.