AS-252424
900515-16-4
99%
2026-08-25
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName AS-252424 Cat No CEI-0088 Description AS-252424, a ATP-competitive and selective small-molecule PI3K-gamma inhibitor, can potently inhibit PI3K-gamma with IC50 of 33 nM . CAS No 900515-16-4 Molecular Weight 305.28 Purity >99% Storage 2 years at -20 centigrade Targets PI3K-gamma Molecular Formula C14H8FNO4S Chemical Name (Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione Solubility DSMO 61 mg/mL Water In vitro AS-252424, a ATP-competitive and selective small-molecule PI3K-gamma inhibitor, can potently inhibit PI3K-gamma with IC50 of 33 nM . By inhibiting PI3K-gamma, AS-252424 can decrease Ca 2+ in HL-1 cell mouse cardiomyocytes. AS252424 also can decrease the proliferation of 5 medulloblastoma cell lines, including DAOY and PFSK cells in a dose-dependent manner, with IC50 values in the range of 1 to 15 umol/L. But AS252424 do not shows strong inhibition to cell lines with low PI3K-gamma expression. In addition, 24-hour-treatment with AS252424 enhanced cisplatin-induced apoptosis in medulloblastoma cells. In vivo Oral administration of AS-252424 in a mouse model of acute peritonitis led to a significant reduction of leukocyte recruitment. category Inhibitors(c1514) cas_num 900515-16-4 Basic Info-
Product Name:
5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
Other Name:5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione;AS-252424;(E)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)Methylene)thiazolidine-2,4-dione;(Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione;AS 2524245-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione;(5Z)-5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
CAS No.:900515-16-4
Molecular Formula:C14H8FNO4S
InChIKeys:OYYVWNDMOQPMGE-SDQBBNPISA-N
Molecular Weight:305.28
Exact Mass:305.015808
UNII:63D4RUV1GN
Categories:
Characteristics-
PSA:
104.84000
XLogP3:2.14
Appearance:yellow
Density:1.6±0.1 g/cm3
Refractive Index:1.692
Water Solubility:DMSO: >20mg/mL
Storage Conditions:2-8°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product