AZD6244(Selumetinib)
606143-52-6
99%
2026-07-17
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName AZD6244(Selumetinib) Cat No CEI-0164 Description AZD6244(Selumetinib) can inhibit MEK with IC50 of 14 nM. Alias ARRY-142886 CAS No 606143-52-6 Molecular Weight 457.68 Purity >99% Storage 2 years at -20centigrade Powder Synonyms ARRY-142886 Targets MEK Molecular Formula C17H15BrClFN4O3 Chemical Name 6-(4-bromo-2-chlorophenylamino)-7-fluoro-N-(2-hydroxyethoxy)-3-methyl-3H-benzo[d]imidazole-5-carboxamide Solubility DMSO 92 mg/mL Water In vitro As a potent, selective, and ATP-uncompetitive inhibitor of MAPK/ERK kinase 1/2, AZD6244 (Selumetinib, ARRY-142886) is highly potent to inhibit MEK1 with IC50 of 14 nM. AZD6244 inhibits the MEK-ERK pathway across a spectrum of thyroid cancer cells. MEK inhibition is cytostatic in papillary thyroid cancer and anaplastic thyroid cancer cells bearing a BRAF mutation and may have less impact on thyroid cancer cells lacking this mutation. AZD6244 potently inhibited MEK 1/2 activity in thyroid cancer cell lines regardless of BRAF mutation status, as evidenced by reduced ERK phosphorylation. Four BRAF mutant lines exhibited growth inhibition at low doses of the drug, with GI50 concentrations ranging from 14 to 50 nm, predominantly via a G0/G1 arrest, comparable with findings in a sensitive BRAF mutant melanoma cell line. In vivo Nude mouse xenograft tumors derived from the BRAF mutant line ARO exhibited dose-dependent growth inhibition by AZD6244, with effective treatment at 10 mg/kg by oral gavage. This effect was primarily cytostatic and associated with marked inhibition of ERK phosphorylation. category Inhibitor Drugs(c1439) cas_num 606143-52-6 Basic Info-
Product Name:
Selumetinib
Other Name:1H-Benzimidazole-6-carboxamide,5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-;5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide;ARRY 142886;AZD 6244;Selumetinib;NSC 741O78;G 00039805;6-(4-Bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide;Koselugo;AZD6244;AZD-6244;865610-79-3
CAS No.:606143-52-6
Molecular Formula:C17H15BrClFN4O3
InChIKeys:InChIKey=CYOHGALHFOKKQC-UHFFFAOYSA-N
Molecular Weight:457.685
Exact Mass:457.68
HScode:29349990
Categories:
Characteristics-
PSA:
88.4
XLogP3:3.6
Appearance:White or pale white solid.
Density:1.69
Storage Conditions:Powder stores in -20ºC directly, which is effective for a period of 2 years.
Hazard IdentificationClassification of the substance or mixture
Skin sensitization, Category 1
Serious eye damage, Category 1
Reproductive toxicity, Category 2
Specific target organ toxicity â repeated exposure, Category 2
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H317 May cause an allergic skin reaction
H318 Causes serious eye damage
H361 Suspected of damaging fertility or the unborn child
H373 May cause damage to organs through prolonged or repeated exposure
H411 Toxic to aquatic life with long lasting effects
Precautionary statement(s) Prevention P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P203 Obtain, read and follow all safety instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P317 If skin irritation or rash occurs: Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P317 Get medical help.
P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
P391 Collect spillage.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product