SGX-523
1022150-57-7
99%
2026-07-13
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName SGX-523 Cat No CEI-0059 Description SGX523 can inhibit c-Met with IC50 of 4 nM. CAS No 1022150-57-7 Molecular Weight 359.41 Purity >99% Storage 2 years at -20centigrade Powder Targets c-Met Molecular Formula C18H13N7S Chemical Name 6-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylthio)quinoline Solubility DMSO 2 mg/mL Water In vitro SGX523 is a novel and selective APT- competitive inhibitor which can inhibit c-Met with IC50 of 4 nM. SGX523 is >1,000-fold selective versus the >200-fold selectivity of other protein kinases tested in biochemical assays. SGX523 inhibited MET-mediated signaling, cell proliferation, and cell migration at nanomolar concentrations but had no effect on signaling dependent on other protein kinases. And SGX523 inhibit c-Met with the dose-dependent manner. category Inhibitors(c1514) cas_num 1022150-57-7 Basic Info-
Product Name:
6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline
Other Name:Quinoline,6-[[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-;6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline;SGX 523;1072116-01-8
CAS No.:1022150-57-7
Molecular Formula:C18H13N7S
InChIKeys:InChIKey=BCZUAADEACICHN-UHFFFAOYSA-N
Molecular Weight:359.42
Exact Mass:359.41
EC Number:-0
UNII:WH8SQN09KJ
DSSTox ID:DTXSID70647300
Categories:
Characteristics-
PSA:
99.1
XLogP3:2.4
Density:1.485
Refractive Index:1.817
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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