CGS 21680
120225-54-9
0.98%
2026-08-13
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName CGS 21680 Cat No CEI-1277 Description CGS 21680 is agonist of A2A adenosine receptor with Ki value of 27 nM. Product Overview CGS 21680 is a selective agonists of A2 adenosine receptor with IC50 value of 22nM. CGS 21680 is found to be potent and selective adenosine A2 receptor agonists. In a radioligand binding in vitro assay, CGS 21680 binds A2 receptor with IC50 value of 22nM and the A1/A2 ratio is 141, In the perfused rat heart model, CGS 21680 can increase coronary flow with greater EC25 value than 1000nM. It shows a good separation between its ability to induce vasorelaxation and bradycardia. CGS 21680 also has potent effect on blood pressure in vivo with EC25 value of 9µg/kg and it can induce an increase in heart rate. It is reported that CGS 21680 also has the potency of anti-inflammatory. It can reduce the development of acute lung inflammation in a mouse model of carrageenan-induced pleurisy. In both prior and post-treatment, CGS 21680 can reduce the number of inflammatory cells and the degree of lung injury. CAS No 120225-54-9 Molecular Weight 499.52 Purity 0.98 Storage Store at -20°C Synonyms CGS-21680; CGS21680 Targets A2A adenosine receptor IC50 27 nM (Ki) Molecular Formula C23H29N7O6 Chemical Name 3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Amides(c1311) cas_num 120225-54-9 Basic Info-
Product Name:
CGS21680
Other Name:Benzenepropanoic acid,4-[2-[[6-amino-9-(N-ethyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]-;4-[2-[[6-Amino-9-(N-ethyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic acid;CGS 21680;124182-57-6;160009-89-2;1169605-34-8;1254644-99-9
CAS No.:120225-54-9
Molecular Formula:C23H29N7O6
InChIKeys:InChIKey=PAOANWZGLPPROA-RQXXJAGISA-N
Molecular Weight:499.5
Exact Mass:499.52
UNII:T5HB1E831H
DSSTox ID:DTXSID6043882
Categories:
Characteristics-
PSA:
198
XLogP3:0.88070
Density:1.6
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product