LY2811376
1194044-20-6
0.98%
2026-07-15
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName LY2811376 Cat No CEI-1409 Product Overview LY2811376 is a non-peptidic inhibitor of BACE1.Beta-secretase 1 (BACE1) is an aspartic-acid protease that cleaves the amyloid precursor protein (APP) into amyloid-β peptide (Aβ), which plays a critical role in Alzheimer's disease (AD). In recombinant enzyme assays, LY2811376 inhibited hBACE1 with IC50 values of 249 nM and 239 nM against a larger chimeric protein substrate and a small synthetic peptide, respectively. In a human embryonic kidney cell line overexpressed APP, LY2811376 decreased Aβ secretion with EC50 value of 300 nM in a concentration-dependant way. In SH-SY5Y cells, LY2811376 reduced Aβ 1-40 and Aβ 1-42 secreted to the cell medium while increased the level of Aβ 5-40. In the APPV717F mouse, LY2811376 significantly reduced Aβ, as well as sAPP and C99, the cleavage products of APP by BACE1.In a healthy population (n =18), LY2811376 (30 mg, 90 mg) increased Aβ 5-40 and Aβ 5-X in a dose-dependant way, while Aβ 1-34 reduced in a same way. These results suggested that LY2811376 inhibited N-terminally truncated Aβ peptides in a BACE1-independent pathway. CAS No 1194044-20-6 Molecular Weight 320.4 Purity 0.98 Storage Store at -20°C Targets BACE1 Molecular Formula C15H14F2N4S Chemical Name (4S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine Solubility Soluble in DMSO > 10 mM Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Inhibitors(c1514) cas_num 1194044-20-6 Basic Info-
Product Name:
LY2811376
Other Name:LY2811376;(4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine;LY 2811376,(4S)-4-[2,4-Difluoro-5-(5-pyriMidinyl)phenyl]-5,6-dihydro-4-Methyl-4H-1,3-thiazin-2-aMine;(S)-4-(2,4-difluoro-5-(pyriMidin-5-yl)phenyl)-4-Methyl-5,6-dihydro-4H-1,3-thiazin-2-aMine;(4S)-4-(2,4-difluoro-5-pyriMidin-5-ylphenyl)-4-Methyl-5,6-dihydro-1,3-thiazin-2-aMine;N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride Tubastatin A HClLY2811376;LY2811376, >=98%
CAS No.:1194044-20-6
Molecular Formula:C15H14F2N4S
InChIKeys:MJQMRGWYPNIERM-HNNXBMFYSA-N
Molecular Weight:320.3602664
Exact Mass:320.090729
EC Number:-0
UNII:UR18YJ97SJ
DSSTox ID:DTXSID10658051
HScode:2934999090
Categories:
Characteristics-
PSA:
89.5
XLogP3:2.1
Density:1.42
Boiling Point:486.5±55.0 °C(Predicted)
Flash Point:248.0±31.5 °C
Refractive Index:1.662
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product