N3PT
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CAS No.:
13860-66-7
Content:
0.98%
Price valid (until):
2026-09-21
Company Type:
Manufactory
Location:
United States
Qualification:
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Description
ProductName N3PT Cat No CEI-1437 Product Overview N3PT is a potent and selective TK inhibitor both in vitro and in vivo. CAS No 13860-66-7 Molecular Weight 336.28 Purity 0.98 Storage Store at -20°C Synonyms N3-pyridyl thiamine Targets TK IC50 22 nM(Apo-TK); 26 nM (EC50, Cellular TK) Molecular Formula C13H19Cl2N3OS Chemical Name 2-[3-[(2-amino-6-methylpyridin-3-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol; chloride; hydrochloride Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request In vitro N3PT inhibits transketolase activity in a cell based assay. Competitive inhibition of TK by N3PT in cells treated with increasing doses of thiamine, expressed as percentage enzymatic activity (the slope of initial linear range) of controls not treated with compounds. In vivo Tumors were induced in mice at day 0 and mice were then treated at day 7 with vehicle alone or with N3PT. Low-thiamine diet enhances the sensitivity to N3PT inhibition of TK in spleen. Animals were switched to diets containing 16.5 mg/kg (unchanged), 5 mg/kg, 1 mg/kg, or 0 mg/kg thiamine, from a normal chow containing 16.5mg/kg thiamine. category Specialty Chemicals(c26) cas_num 13860-66-7 Basic Info-
Product Name:
N3PT
CAS No.:13860-66-7
Categories:
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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