VTP-27999 Hydrochloride
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CAS No.:
1264191-73-2
Content:
0.98%
Price valid (until):
2026-06-30
Company Type:
Manufactory
Location:
United States
Qualification:
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Description
ProductName VTP-27999 Hydrochloride Cat No CEI-1575 Description VTP-27999 Hydrochloride is a potent inhibitor of renin with IC50 value of 0.3 nM for human renin. Product Overview VTP-27999 hydrochlorideis a highly potent and selective renin inhibitor (IC50 = 0.47 nM). It exhibits >1000 selectivity for renin over >150 receptors, ion channels and enzymes. VTP-27999 hydrochloride is hydrochloride salt form of VTP-27999.Renin is an asparyl protease that cleaves angiotensinogen into angiotension I in the plasma. It functions as a regulator of blood pressure and sodium homeostasis. In vitro, VTP-27999 increases renin immunoreactivity by >30%, it bind to acid-activated, intact prorenin and promotes immunoreactivity in a renin assay. In vascular smooth muscle cells, VTP-27999 also blocks renins ability to activate extracellular signal-regulated kinase 1/2 phosphorylation. In double transgenic rats engineered to express human renin and angiotensinogen with severe hypertension, 24 h treatment of 10 mg/kg VTP-27999 induces a greater reduction in mean arterial blood pressure and a longer duration of action. CAS No 1264191-73-2 Molecular Weight 561.54 Purity 0.98 Storage Store at -20°C Synonyms VTP27999 Hydrochloride; VTP 27999 Hydrochloride Targets human renin IC50 0.3 nM Molecular Formula C26H42Cl2N4O5 Chemical Name methyl N-[2-[(R)-(3-chlorophenyl)-[1-[[(2S)-2-(methylamino)-3-[(3R)-oxan-3-yl]propyl]carbamoyl]piperidin-3-yl]methoxy]ethyl]carbamate; hydrochloride Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 1264191-73-2 Basic Info-
Product Name:
VTP-27999 (Hydrochloride)
CAS No.:1264191-73-2
Categories:
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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