high purity hot sale Bardoxolone 99% high quality see COA KANBEI
218600-44-3
Industrial Grade
99%
SHANGHAI
KANBEI
25kg drum
2023-12-31
PVC resin,pvc paste resin,melamine
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceBardoxolone is a novel nuclear regulator factor (Nrf-2) activator.
Bardoxolone is a member of cyclohexenones.|Bardoxolone has been used in trials studying the treatment of LYMPHOMA and Solid Tumors. It is a synthetic triterpenoid and a highly potent activator of redox-sensitive signaling pathways that induce programmed cell death (apoptosis) in cancer cells that are under high levels of intrinsic oxidative stress. In contrast, Bardoxolone in normal cells induces protective antioxidant/anti-inflammatory responses.|Bardoxolone is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities. Bardoxolone blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis. This agent also inhibits the interleukin-1 (IL-1)-induced expression of the pro-inflammatory proteins matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-13 (MMP-13) and the expression of Bcl-3; Bcl-3 is an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression.Basic Info-
Product Name:
Bardoxolone
Other Name:2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid;Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-;Bardoxolone;CDDO;RTA 401;2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid;Bardoxolone (CDDO);(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10-oxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicene-4a(2H)-carboxylic acid
CAS No.:218600-44-3
Molecular Formula:C31H41NO4
InChIKeys:TXGZJQLMVSIZEI-UQMAOPSPSA-N
Molecular Weight:491.66154
Exact Mass:491.303558
UNII:7HT68L8941
NSC Number:711193
NCI Thesaurus Code:C48382
Categories:
Characteristics-
PSA:
95.2 Ų
Density:1.2±0.1 g/cm3
Melting Point:180-182 °C
Boiling Point:632.9°C at 760 mmHg
Flash Point:336.6±31.5 °C
Refractive Index:1.575
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
PVC resin,pvc paste resin,melamine
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Location:
Room 405, Unit 2, Building 1, Taiji Mansion, No. 38, Nanyang Road, Jinshui District, Zhengzhou City, Henan Province
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Payment Terms:
TT against copy of documents,L/C
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Average lead Time:
90
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
11-50
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Year of Establishment:
2022
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