Azelnidipine -a
123524-52-7
25
2023-02-27
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceYellow SolidAzelnidipine, a member of the 1,4-dihydropyridine class of L-type calcium channel blockers with a slow onset profile, was marketed in Japan for the treatment of hypertension. Azelnidipine is synthesized via the condensation of iso-propyl 2-(3- nitrobenzylidene)acetoacetate with (1-diphenylmethylazetidin-3-yl)-3,3-diamino acrylate. The diamino acrylate intermediate is prepared from the cyanoacetic ester by sequential treatment with HCl and ammonia. In receptor binding studies usi
Azelnidipine is an isopropyl ester.|Azelnidipine is a dihydropyridine calcium channel blocker. It is marketed by Daiichi-Sankyo pharmaceuticals, Inc. in Japan. It has a gradual onset of action and produces a long-lasting decrease in blood pressure, with only a small increase in heart rate, unlike some other calcium channel blockers. It is currently being studied for post-ischemic stroke management.Basic Info-
Product Name:
Azelnidipine
Other Name:3,5-Pyridinedicarboxylic acid,2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-,3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester;3,5-Pyridinedicarboxylic acid,2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-,3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester,(±)-;CS 905;3-[1-(Diphenylmethyl)-3-azetidinyl] 5-isopropyl (±)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate;Azelnidipine;Calblock;2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3-yl) 5-isopropyl ester;3-O-(1-Benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;116573-93-4
CAS No.:123524-52-7
Molecular Formula:C33H34N4O6
InChIKeys:InChIKey=ZKFQEACEUNWPMT-UHFFFAOYSA-N
Molecular Weight:582.65
Exact Mass:582.65
EC Number:1806241-263-5
DSSTox ID:DTXSID3020120
HScode:2933990090
Categories:
Characteristics-
PSA:
140
XLogP3:6
Appearance:light yellowish powder
Density:1.33±0.1 g/cm3(Predicted)
Melting Point:95-98 °C
Boiling Point:709.3±60.0 °C(Predicted)
Flash Point:382.8±32.9 °C
Refractive Index:1.659
Water Solubility:Insoluble in water;DMSO: >10mg/mL
Storage Conditions:room temp
Vapor Pressure:5.74E-20mmHg at 25°C
Toxicity:LD50 in female, male mice, female, male rats (mg/kg): 785, 979, 1267, 1971 orally
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Serious eye damage, Category 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H302 Harmful if swallowed
H318 Causes serious eye damage
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P317 Get medical help.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Location:
https://www.dideu.com/en/
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7 days
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Total Annual Revenue:
Above $100 million
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Total Employees:
Above 1000
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Year of Establishment:
2016
Company Certificates-
ISO Certificate
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REACH
">Company Profile -
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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