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Danthron,1,8-Dihydroxyanthraquinone,117-10-2,98%,hot sells

Name: Danthron,1,8-Dihydroxyanthraquinone,117-10-2,98%,hot sells
Brand: kindchem
SKU: pr2308021192
Price: 1 USD
Availability: InStock

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CAS No.:

117-10-2

Grade:

Industrial Grade

Content:

98%

Port:

shanghai

Brand:

kindchem

Packaging:

25kg/drum

Price valid (until):

2023-08-15

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Kindchem Co., Ltd

Company Type:

Trader

Location:

China

Qualification:

Main Products:

API OLED Organic intermediate,1-Cyclopentene-1-carbonitrile ,Cyclohexanol, 4-chloro- ,1,3-Cyclohexanedione,2,2-Dimethyl-1,3-cyclohexanedione,6-Bromo-1,2,3,4-tetrahydroquinoline

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Product Description
Seller Information
Inquiry History

Description

Danthron (0.1, 1, and 10 μM) dose-dependently promotes the phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in both HepG2 and C2C12 cells. Meanwhile, Danthron treatment significantly reduces the lipid synthesis related sterol regulatory element-binding protein 1c (SREBP1c) and fatty acid synthetase (FAS) gene expressions, and the total cholesterol (TC) and triglyceride (TG) levels. In addition, Danthron treatment efficiently increases glucose consumption. Danthron effectively reduces intracellular lipid contents and enhances glucose consumption in vitro via activation of AMPK signaling pathway. 10 μM Danthron/24 h is safe for HepG2 cells. With 80% confluence, HepG2 cells are incubated with Danthron (0.1-10 μM) in FBS-Free media for 8 h. Subsequently, cells are harvested for Western blot assay. Danthron increases the p-AMPK protein in a dose-dependent manner, and no changes in t-AMPK protein are observed. Danthron inhibits 9-cis retinoic acid (9cRA)-induced retinoic X receptor α (RXRα) transactivation by IC 50 at 0.11 μM. To further clarify the stoichimetric ratio of Danthron binding to RXRα-ligand-binding domain (LBD), isothermal titration calorimetry (ITC) experiment is performed. The K D value of Danthron binds to RXRα-LBD by ITC experiment is determined at 7.5 μM.

Product Detail

Items	Specifications

Basic Info

Product Name:

1,8-Dihydroxyanthraquinone

Other Name:

9,10-Anthracenedione,1,8-dihydroxy-;Anthraquinone,1,8-dihydroxy-;1,8-Dihydroxy-9,10-anthracenedione;Altan;Antrapurol;Chrysazin;Danthron;Dantron;Diaquone;1,8-Dihydroxyanthraquinone;Dionone;Istin;Istizin;Dorbane;Laxipurin;Zwitsalax;Laxanorm;Laxanthreen;Laxipur;1,8-Dihydroxy-9,10-anthraquinone;1,8-Dioxyanthraquinone;Danthrone;Modane;NSC 38626;NSC 646568;NSC 7210;1,8-Dihydroxy-9,10-dihydroanthracene-9,10-dione;32073-07-7;343235-40-5

CAS No.:

117-10-2

Molecular Formula:

C14H8O4

InChIKeys:

InChIKey=QBPFLULOKWLNNW-UHFFFAOYSA-N

Molecular Weight:

240.21

Exact Mass:

240.21

BRN:

2054727

EC Number:

204-173-5

UNII:

Z4XE6IBF3V

NSC Number:

755828|646568|38626|7210

UN Number:

2811

DSSTox ID:

DTXSID9020328

NCI Thesaurus Code:

C44363

Color/Form:

Red or red-yellow needles or leaves (from alcohol)|Orange needles from alcohol|Orange powder or reddish-brown needles

ATC Code:

A - Alimentary tract and metabolism

HScode:

29146990

Categories:

Characteristics

PSA:

74.6

XLogP3:

3.2

Appearance:

Orange-brown or brown Powder

Density:

1.3032 (rough estimate)

Melting Point:

193 °C

Boiling Point:

Sublimes

Flash Point:

>200°C

Refractive Index:

1.5430 (estimate)

Water Solubility:

Almost insoluble in water (6.5X10-6 mols/L at 25 deg C), in alcohol (1:2000). Moderately soluble in ether (1:500), in chloroform; soluble in 10 parts hot glacial acetic acid. Very slightly soluble in aqueous solutions of alkali hydroxides: about 0.8 g dissolves in 100 ml 0.5N NaOH.

Storage Conditions:

Refrigerator

Vapor Pressure:

8.6X10-10 mm Hg at 25 deg C (est)

Vapor Density:

8.3 (Air = 1)

Toxicity:

LD50 orally in mice: <7 g/kg (Case)

Henrys Law Constant:

Henry's Law constant = 5.5X10-11 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pKa1 = 8.45 (phenol); pKa2 = 10.85 (phenol) (est)

Collision Cross Section:

148.3 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Experimental Properties:

When heated to decomposition it emits acrid smoke and irritating fumes|Hydroxyl radical reaction rate constant = 2.6X10-11 cu cm/molec-sec at 25 °C (est)

Air and Water Reactions:

Insoluble in water.

Reactive Group:

Ketones

Reactivity Profile:

DANTHRON is incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides.

See More 1,8-Dihydroxyanthraquinone Properties 

Hazard Identification

Classification of the substance or mixture

Carcinogenicity, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H351 Suspected of causing cancer
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Do not store above 30 deg C.

See More 1,8-Dihydroxyanthraquinone Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
API OLED Organic intermediate,1-Cyclopentene-1-carbonitrile,Cyclohexanol, 4-chloro-,1,3-Cyclohexanedione,2,2-Dimethyl-1,3-cyclohexanedione,6-Bromo-1,2,3,4-tetrahydroquinoline

Location:
No.8 Huangguang Road Qinhuai District Nanjing City Jiangsu China

Payment Terms:
TT against copy of documents,D/P,L/C,100% TT in advance

Average lead Time:
7

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
11-50

Year of Establishment:
2011

Active as a professionally chemicals supplier, Kindchem(Nanjing) Co.,Ltd ,established in 2011,located in Nanjing City,is committed to serve it's clients with a diverse range of chemicals.
We are specialized in the development and manufacture of electric chemicals including Liquid crystal OLED and OPV materials,pharmaceutical intermediates and other speciality chemicals.We are also engaged in Custom synthesis and contract manufacturing to meet the different requirements from clients worldwide.
Strengthened technical exchange and cooperation with surrounding universities and research institutes, we constantly enhanced its independent research and development capabilities and improved product quality by using the rich technology, information and resources from them, so as to guarantee the innovative development of enterprises.
Adhering to the business philosophy of being kind to people and friendly to the environment, the company strives for survival by quality and development by reputation. It is willing to cooperate with people of insight and new and old customers to grow together and contribute to the sustainable development of the chemical industry.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
Saudi Arabia	1,8-Dihydroxyanthraquinone	100 KG	Aug 1, 2023

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Danthron,1,8-Dihydroxyanthraquinone,117-10-2,98%,hot sells

Product Description

Seller Information