Factory Supply High Quality Ammonium Chloride CAS 12125-02-9

Biological activity of ammonium chloride
Description Ammonium chloride, as a heteropolar compound regulating pH value, can cause intracellular alkalization and metabolic acidosis, thus affecting enzyme activity and the process of biological systems. Ammonium chloride is an autophagy inhibitor [1][2].
Related category
Research Areas >> Cancer
Signaling Pathway >> Autophagy >> Autophagy
In vitro studies, ammonium chloride (NH4Cl), a lysosomal inhibitor, can increase the lysosomal pH and reduce reovirus production during infection of mouse L cells [2].
In vivo studies Ammonium chloride (0.28M in drinking water) promotes the survival of cardiomyocytes in vivo by reducing systolic dysfunction, myocardial hypertrophy, inflammation, apoptosis, and autophagy [1]. Animal model: C57B/L6 mice aged 8-9 weeks [1] Dose: 0.28M in drinking water (5mg/kg adriamycin, once a week, for 2 weeks) Administration: 0.28M in drinking water (5mg/kg adriamycin, once a week, for 2 weeks) Results: Effective improvement of doxorubicin (DOX) -induced myocardial apoptosis and cardiac dysfunction in mice.