Factory Supply High Quality Silicified microcrystalline cellulose 99% Solid CAS9004-34-6

Bioactivity of microcrystalline cellulose
Description Cellulose can be used as an excipient. Pharmaceutical excipients, or pharmaceutical excipients, refer to other chemical substances used in the pharmaceutical process in addition to pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs [1].
Related category
Field of Study >> Other
Signal Path >> Other >> Other
Target point
Human Endogenous Metabolite

reference
[1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25; 87:88-99.

Physical and chemical properties of microcrystalline cellulose
Density 0.9± 0.1g /cm3
Boiling point 237.6±35.0 °C at 760 mmHg
Melting point 260-270ºC
Molecular formula C6H10O5
Molecular weight 160.255
Flash point 91.8±14.5 °C
Accurate mass 160.125198
LogP 4.75
Appearance Pink powder
Vapor pressure 0.1±0.2 mmHg at 25°C
Refractive index 1.529
Storage condition
1. The plastic bag is sealed with a gunny bag. Store in a cool and dry place, avoid high humidity and high temperature.

stability
1. Stable at normal temperature and pressure, can be compressed into sheets, can be dispersed in water, can absorb water and swell.

2. Avoid light, open flame, high temperature,

Water solubility insoluble | insoluble
Computational chemistry
1. Reference value of hydrophobic parameter calculation (XlogP) :-4.7

2. Number of hydrogen bond donors :8

3. Number of hydrogen bond receptors :11

4. Number of rotatable bonds :4

5. Number of tautomers: None

6. Topological molecular polar surface area 190

7. Number of heavy atoms :23

8. Surface charge :0

9. Complexity :382

10. Number of isotope atoms :0

11. Determine the number of protonic centers :6

12. Number of uncertain atomic stereocentes :4

13. Determine the number of chemical bond structure centers :0

14. Number of uncertain chemical bond stereocenter :0

15. Number of covalent bond units :1

more
1. Properties: white or off-white fine crystalline powder, odorless, tasteless.

2. Density (g/mL,20℃) : 1.27-1.60

3. Relative vapor density (g/mL, air =1) : not determined

4. Melting point (ºC) : 260-270

5. Boiling point (ºC, atmospheric pressure) : not determined

6. Boiling point (ºC,5.2kPa) : not determined

7. Refractive index: 1.604

8. Flash point (ºC) : 164

9. Specific rotation (º) : not determined

10. Spontaneous ignition point or ignition temperature (ºC) : not determined

11. Vapor pressure (kPa,20ºC) : not determined

12. Saturated vapor pressure (kPa,60ºC) : not determined

13. Heat of combustion (KJ/mol) : not determined

14. Critical temperature (ºC) : not determined

15. Critical pressure (KPa) : not determined

16. Value of oil-water (octanol/water) distribution coefficient: not determined

17. Upper explosion limit (%,V/V) : not determined

18. Lower explosive limit (%,V/V) : not determined

19. Solubility: Insoluble in water, dilute acid, dilute alkali and most organic solvents. Slightly soluble in sodium hydroxide solution and hot casein sodium solution