| Identified uses | Industrial and scientific research use. |
| Uses advised against | no data available |
SECTION 2: Hazard identification
2.1Classification of the substance or mixture
Flammable liquids, Category 3
Specific target organ toxicity – single exposure, Category 3
2.2GHS label elements, including precautionary statements
| Pictogram(s) |   |
| Signal word | Warning |
| Hazard statement(s) | H226 Flammable liquid and vapour H336 May cause drowsiness or dizziness |
| Precautionary statement(s) |
| Prevention | P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. |
| Response | P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell. |
| Storage | P403+P235 Store in a well-ventilated place. Keep cool. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3Other hazards which do not result in classification
SECTION 3: Composition/information on ingredients
3.1Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
| N-butyl acetate | N-butyl acetate | 123-86-4 | 204-658-1 | 100% |
SECTION 4: First-aid measures
4.1Description of necessary first-aid measures
If inhaled
Fresh air, rest. Refer for medical attention.
Following skin contact
Remove contaminated clothes. Rinse skin with plenty of water or shower.
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Rinse mouth. Do NOT induce vomiting. Refer for medical attention .
4.2Most important symptoms/effects, acute and delayed
SKIN: prolonged or frequently repeated exposures may lead to drying. INHALATION: headaches, dizziness, nausea, irritation of respiratory passages and eyes. (USCG, 1999)
4.3Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Esters and related compounds
SECTION 5: Fire-fighting measures
5.1Suitable extinguishing media
Water in straight hose stream will scatter and spread fire and should not be used.
5.2Specific hazards arising from the chemical
Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)
5.3Special protective actions for fire-fighters
Use AFFF, alcohol-resistant foam, dry powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.
SECTION 6: Accidental release measures
6.1Personal precautions, protective equipment and emergency procedures
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable metal or glass containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
6.2Environmental precautions
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable metal or glass containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
6.3Methods and materials for containment and cleaning up
1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. For small quant, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be collected and atomized in a suitable combustion chamber. Butyl acetate should not be allowed to enter a confined space, such as a sewer, because of the possibility of an explosion.
SECTION 7: Handling and storage
7.1Precautions for safe handling
NO open flames, NO sparks and NO smoking. Above 22°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2Conditions for safe storage, including any incompatibilities
Fireproof. Separated from strong oxidants, strong bases and strong acids. Cool.IN GENERAL, MATERIALS ... TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS ... SHOULD BE STORED IN COOL ... VENTILATED PLACE, OUT OF ... SUN, AWAY FROM ... FIRE HAZARD ... BE PERIODICALLY INSPECTED & MONITORED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED ...
SECTION 8: Exposure controls/personal protection
8.1Control parameters
Occupational Exposure limit values
TLV: 50 ppm as TWA; 150 ppm as STEL.MAK: 480 mg/m3, 100 ppm; peak limitation category: I(2); pregnancy risk group: C
Biological limit values
8.2Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear safety goggles or eye protection in combination with breathing protection.
Skin protection
Respiratory protection
Use ventilation, local exhaust or breathing protection.
Thermal hazards
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Liquid. |
| Colour | Clear. |
| Odour | PLEASANT, BANANA-LIKE ODOR |
| Melting point/freezing point | -77.9 °C. |
| Boiling point or initial boiling point and boiling range | >= 125 - <= 126 °C. Atm. press.:Ca. 1 atm. |
| Flammability | Class IB Flammable Liquid: Fl.P. below 73°F and BP at or above 100°F. |
| Lower and upper explosion limit/flammability limit | Lower flammable limit: 1.3% by volume; Upper flammable limit: 7.6% by volume |
| Flash point | 22 °C. Atm. press.:1 atm. |
| Auto-ignition temperature | 425 °C. Remarks:797 degree F autoignition temperature. |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | 1.002 mPa s at 0 deg C; 0.685 mPa s at 25 deg C; 0.500 mPa s at 50 deg C; 0.383 mPa s at 75 deg C; 0.305 mPa s at 100 deg C |
| Solubility | Insoluble in water |
| Partition coefficient n-octanol/water | log Pow = 1.82. Remarks:Temperature and pH not known. |
| Vapour pressure | 20 hPa. Temperature:25 °C. Remarks:15 mm Hg at 77 degree F. |
| Density and/or relative density | > 0.879 - < 0.881 g/cm³. Temperature:20 °C. |
| Relative vapour density | 4 (vs air) |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1Reactivity
1700 PPM [IDLH based on 10% of the lower explosive limit for safety considerations even though the relevant toxicological data indicated that irreversible health effects or impairment of escape existed only at higher concentrations.]
Reacts with strong oxidants, strong acids and strong bases. This generates fire and explosion hazard. Attacks many plastics and rubber.
10.2Chemical stability
Heat /contributes to instability/.
10.3Possibility of hazardous reactions
Flammable liquid.The vapour is heavier than air and may travel along the ground; distant ignition possible.BUTYL ACETATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Attacks many plastics. [Handling Chemicals Safely 1980. p. 233].
10.4Conditions to avoid
10.5Incompatible materials
Contact with nitrates, strong oxidizers, strong alkalies, and strong acids may cause fires and explosions.
10.6Hazardous decomposition products
When heated to decomp it emits acrid smoke and irritating fumes.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male) - 12 760 mg/kg bw.
- Inhalation: LC50 Rat inhalation >8.82 mg/L/6 hr
- Dermal: no data available
Skin corrosion/irritation
Serious eye damage/irritation
Respiratory or skin sensitization
Germ cell mutagenicity
Carcinogenicity
Reproductive toxicity
STOT-single exposure
The substance is irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.
STOT-repeated exposure
The substance defats the skin, which may cause dryness or cracking.
Aspiration hazard
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C.
SECTION 12: Ecological information
12.1Toxicity
- Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill); Conditions: static bioassay in fresh water, mild aeration applied after 24 hr, 23 deg C; Concentration: 100 ppm for 96 hr
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Artemia salina - 32 mg/L - 48 h.
- Toxicity to algae: EC50 - Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) - 674.7 mg/L - 72 h.
- Toxicity to microorganisms: no data available
12.2Persistence and degradability
Biological oxygen demand: 0.15 to 0.5 lb/lb, 5 days (theoretical) 52%.
12.3Bioaccumulative potential
An estimated BCF of 7 was calculated in fish for n-butyl acetate(SRC), using a log Kow of 1.78(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of n-butyl acetate can be estimated to be 19(SRC). According to a classification scheme(2), this estimated Koc value suggests that n-butyl acetate is expected to have very high mobility in soil.
12.5Other adverse effects
SECTION 13: Disposal considerations
13.1Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1UN Number
| ADR/RID: UN1123 (For reference only, please check.) | IMDG: UN1123 (For reference only, please check.) | IATA: UN1123 (For reference only, please check.) |
14.2UN Proper Shipping Name
| ADR/RID: BUTYL ACETATES (For reference only, please check.) | IMDG: BUTYL ACETATES (For reference only, please check.) | IATA: BUTYL ACETATES (For reference only, please check.) |
14.3Transport hazard class(es)
| ADR/RID: 3 (For reference only, please check.) | IMDG: 3 (For reference only, please check.) | IATA: 3 (For reference only, please check.) |
14.4Packing group, if applicable
| ADR/RID: II (For reference only, please check.) | IMDG: II (For reference only, please check.) | IATA: II (For reference only, please check.) |
14.5Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6Special precautions for user
14.7Transport in bulk according to IMO instruments
SECTION 15: Regulatory information
15.1Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
| N-butyl acetate | N-butyl acetate | 123-86-4 | 204-658-1 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. |
| EC Inventory | Listed. |
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. |
| China Catalog of Hazardous chemicals 2015 | Listed. |
| New Zealand Inventory of Chemicals (NZIoC) | Listed. |
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. |
| Vietnam National Chemical Inventory | Listed. |
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. |
| Korea Existing Chemicals List (KECL) | Listed. |
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
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