Pharmacy Grade Heparin sodium CAS No 9041-08-1 API

Product Name: Heparin Sodium
CAS No: 9041-08-1
EINECS No: 232-681-7
Molecular Formular: (C12H16NS2Na3)20
Molecular Weight: 288.42800
Appearance: White powder
Storage:Store in cool and dry places, keep away from strong light.
Shelf life:2 years when properly stored

Heparin Sodium (Heparin Sodium) is Heparin Sodium sulfate glycosaminoglycan anticoagulants.Heparin is from pigs or cows in the intestinal mucosa of extraction of amino sulfate sodium salt, mucopolysaccharide material.In recent years, studies have shown that heparin and fall hematic fat action.
This product is white or kind of white powder, have led to wet.This product is soluble in water. Take this product than the curl, precision said, adding water to dissolve and diluted into each 1ml contains 2.5mg of solution, agarose gel electrophoresis test, the test and the ratio of the standard show spots by the migration distance is 0.9-1.1.

Function

1.The treatment of various diseases concurrent disseminated intravascular coagulation early. 
2. Prevention of arterial and venous thrombosis and pulmonary embolism.
3.Treatment of arterial and venous thrombosis and pulmonary embolism, ischemic stroke, unstable angina (to alleviate the symptoms, prevention of myocardial infarction), acute myocardial infarction (prevention of early reinfarction and infarct extension, reduce mortality). 
4.The artificial lung, peritoneal dialysis or hemodialysis as anticoagulants.
5.thrombolytic therapy as maintenance therapy. 
6.used for the prevention of blood coagulation and blood bank transfusion of blood and other body save anticoagulants.

Application

Heparin sodium salt can delay or prevent blood coagulation in vitro and in vivo. Its mechanism of action is very complicated which involves many processes of coagulation process. Its role is to:
1. inhibit the formation and function of thromboplastin, thus preventing the conversion of prothrombin into thrombin;
2. Inhibit the thrombin and other coagulation factors at relative high concentrations, preventing the conversion of fibrinogen to fibrous proteins;
3. prevent platelet aggregation and destruction.
In addition, the anticoagulant effect of Heparin sodium salt is still related to the negatively charged sulfate inside its molecule. Positively charged alkaline substance such as protamine or toluidine blue can all neutralize its negative charge, thus inhibiting its anticoagulant effect. Because heparin can be activated in vivo and release lipoprotein lipase, hydrolyzing the triglycerides and low-density lipoprotein in chylomicrons, so it also has a lipid-lowering effect.