Clindamycin-ECHEMI

Clindamycin

L-threo-α-D-galacto-Octopyranoside,methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-;L-threo-D-galacto-Octopyranoside,methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-,trans- α-;L-threo-α-D-galacto-Octopyranoside,methyl 7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-,(2S-trans)-;Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside;Clindamycin;Dalacin C;7-Chloro-7-deoxylincomycin;Clinimycin;7-Chlorolincomycin;Cleocin;7(S)-Chloro-7-deoxylincomycin;Sobelin;7-Deoxy-7(S)-chlorolincomycin;7-CDL;U 21251;Chlolincocin;Antirobe;Dalacine;Klimicin;ClindaDerm;Klindan 300;Dalacin V;Clincin;Clindam;13441-63-9;16669-21-9;24620-78-8;24696-19-3;1376624-06-4;1376758-11-0

18323-44-9

C18H33ClN2O5S

InChIKey=KDLRVYVGXIQJDK-AWPVFWJPSA-N

424.98

424.98

242-209-1

DTXSID2022836

Yellow, amorphous solid

D - Dermatologicals|G - Genito urinary system and sex hormones|J - Antiinfectives for systemic use

Antibiotics

127.56000

1.83

1.3±0.1 g/cm3

141 - 143ºC

628.1±55.0 °C at 760 mmHg

333.6±31.5 °C

1.574

>63.7 [ug/mL]|In water, 30.61 mg/L at 25 °C (est)

Store in tight container as defined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity.|Commercially available clindamycin phosphate vaginal cream should be stored in a tight container at 20-25 °C; freezing should be avoided. The vaginal suppositories and clindamycin phosphate vaginal cream should be stored at a controlled room temperature of 25 °C, but may be exposed to temperatures ranging from 15-30 °C; exposure to temperatures exceeding 30 °C or high humidity should be avoided. When stored as recommended, the commercially available vaginal cream is stable for 18 months following the date of manufacture. /Clindamycin phosphate/|The commercially available gel containing clindamycin phosphate (clindamycin 1%) in fixed combination with benzoyl peroxide 5% should be refrigerated at 2-8 °C until dispensed.178 Once dispensed, the gel may be stored at a room temperature up to 25 °C for up to 60 days. The gel should not be frozen. /Clindamycin phosphate/|Commercially available clindamycin phosphate 1% topical gel, lotion, and solution should be stored in tight containers at 20-25 °C; freezing should be avoided. /Clindamycin phosphate/

5.28X10-17 mm Hg at 25 °C (est)

D +214° (chloroform)

Henry's Law constant = 2.89X10-22 atm-cu m/mol at 25 °C (est)

Characteristic taste; odorless or has faint mercaptan-like odor; freely soluble in water, dimethylformamide, methanol; soluble in alcohol; practically insoluble in acetone; pKa: 7.72 in pure water /Clindamycin hydrochloride/

Mol wt: 479.47. White crystals from ethanol-ethyl acetate, mp 141-143 °C. Specific optical rotation = +144 deg at 25 °C/D (water). pKa 7.6. Soluble in water, pyridine, ethanol, DMF /Clindamycin hydrochloride monohydrate/|Mol wt: 504.97. Soluble in water /Clindamycin 2-dihydrogen phosphate/