High Purity Yellow Powder 99% NNMTi 5-amino-1MQ CAS 42464-96-0 5-Amino-1-methylquinolin-1-ium iodide

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5-Amino-1-methylquinolinium iodide, also known as NNMTi, is a chemical compound with significant applications in biological research, particularly related to muscle regeneration and differentiation.

Mechanism of Action

5-Amino-1MQ functions primarily by inhibiting the enzyme NNMT, which is involved in the methylation of nicotinamide and other substrates. By blocking NNMT activity, 5-Amino-1MQ leads to increased levels of nicotinamide adenine dinucleotide (NAD+), a crucial cofactor in cellular metabolism. This increase in NAD+ enhances metabolic processes and energy expenditure while also activating sirtuin-1 (SIRT1), often referred to as the "longevity gene," which plays a role in regulating cellular health and longevity.

Positive Feedback Loop

1. Inhibition of NNMT: Reduces the production of methylated metabolites that can contribute to metabolic dysregulation.
2. NAD+ Restoration: Supports cellular functions such as DNA repair and energy metabolism.
3. Anti-inflammatory Effects: Mitigates inflammation by reducing pro-inflammatory mediators, which can aid in various chronic conditions.

Applications:

1. Weight Management
5-Amino-1MQ has demonstrated efficacy in reducing body weight and white adipose tissue mass without affecting food intake. Studies on diet-induced obese mice showed significant reductions in adipocyte size and overall fat mass.
2. Muscle Regeneration
The compound promotes muscle stem cell activity, enhancing muscle repair and regeneration. It has been shown to rejuvenate satellite cells, which are essential for muscle growth and recovery, particularly in aged muscles.
3. Anti-inflammatory Properties
5-Amino-1MQ exhibits anti-inflammatory effects that may help manage conditions associated with chronic inflammation. This property contributes to its potential use in treating metabolic syndrome and related disorders.
4. Cancer Research
Preliminary studies suggest that 5-Amino-1MQ may disrupt the energy supply to cancer cells by interfering with glycolysis, potentially slowing down cancer cell growth and enhancing the effectiveness of other cancer therapies.

Safety and Side Effects

5-Amino-1MQ appears to have a favorable safety profile based on animal studies. No significant adverse effects were reported at effective doses, including:
No Impact on Food Intake: Treatment did not alter total food consumption in studies.
No Observable Toxicity: Studies indicated no systemic toxicity at tested doses 24.
However, as with any compound, further research is necessary to fully understand its long-term safety profile in humans.

Pharmacokinetics

While specific pharmacokinetic data for 5-Amino-1MQ are limited, general insights include:
Absorption: As a small molecule, it is likely well absorbed when administered subcutaneously.
Distribution: It can cross cell membranes effectively due to its small size and membrane-permeable nature.
Metabolism: The metabolism of 5-Amino-1MQ primarily involves pathways associated with NNMT inhibition.
Half-life: Specific half-life data are not provided but would depend on the route of administration and individual metabolism.

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