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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Ezetimibe for Sale > High Purity low price API 99% CAS163222-33-1 Dabigatran Ezetimibe Powder with Best Price
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High Purity low price API 99% CAS163222-33-1 Dabigatran Ezetimibe Powder with Best Price

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Unit Price: Get Latest Price
CAS No.:

163222-33-1

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

silu

Packaging:

bag

Sample Available:

Yes

Price valid (until):

2025-04-03

Company Type:
Trader
Location:
China
Qualification:
Main Products:

peptide,Weight loss peptide

  • Product Description

  • Seller Information

  • Inquiry History

  • Description


      Product Detail  


    Name:Suki

    WhatsApp: +852 5283 9539

    Email: suki@hnchenchi.com






    Product name dabigatran ezetimibe
    CAS NO. 163222-33-1
    Purity 99%
    Specifications 25kg/bag

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    Paclitaxel is a monomeric diterpene compound extracted from the bark of the natural plant Taxus genus. It is a complex secondary metabolite and the only drug known to date that can promote microtubule polymerization and stabilize polymerized microtubules. Isotope tracing shows that paclitaxel only binds to polymerized microtubules and does not react with unpolymerized tubulin dimers. After cells come into contact with paclitaxel Chemicalbook, a large number of microtubules will accumulate in the cells. The accumulation of these microtubules interferes with various functions of the cells, especially stops cell division in the mitotic phase, blocking the normal division of cells. Through II-III clinical studies, paclitaxel is mainly suitable for ovarian cancer and breast cancer, and also has certain therapeutic effects on lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma, and brain tumors

    Indications: It has good effects in treating ovarian cancer and platinum-resistant refractory ovarian cancer and breast cancer, and has good prospects in treating prostate cancer, head and neck cancer, esophageal cancer, germ cell tumors, endometrial cancer, lymphoma, bladder cancer, upper gastrointestinal cancer, small cell and non-small cell lung cancer.

    Side effects
    Adverse reactions to paclitaxel usually include allergic reactions, bone marrow suppression, neurotoxicity, cardiovascular toxicity, joint and muscle pain, gastrointestinal reactions, liver toxicity, hair loss, etc. The unique adverse reaction of the injection is the allergic reaction to the excipient polyoxyethylated castor oil.

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    Application

     1. Anti-tumor drug. Used to treat metastatic breast cancer and metastatic ovarian cancer. Broad-spectrum anti-tumor herbal medicine;

    2. Effective anti-tumor drug for the treatment of ovarian cancer, breast cancer and other diseases; binds to the N-terminal region of β-tubulin, promotes the formation of highly stable microtubules, resists depolymerization, prevents normal cell division and captures in the G2/M phase of the cell cycle;

    3. An anti-microtubule drug that inhibits depolymerization by promoting tubulin polymerization, maintains tubulin stability, and inhibits cell mitosis. Acting on human endothelial cells, the IC50 is 0.1pM.

    Function

    1.Taxol is a mitotic inhibitor drup used in the treatment of cancer.
    2. Isolated the compound from the bark of the Pacific yew tree, Taxus brevifolia, and noted its antitumor activity in a broad range of rodent tumors.
    3. Taxol has since become an effective tool of doctors who treat patients with lung, ovarian, breast cancer, and advanced forms of Kaposi's sarcoma.
    4.Taxol is also used for the prevention of restenosis (recurrent narrowing) of coronary stents; locally delivered to the wall of the coronary artery, a paclitaxel coating limits the growth of neointima (scar tissue) within stents.



    A: After purchasing the products from our factory, we have A professional technical team and after-sales team to serve you and solve all your problems in the future
    Q2: Can I get some samples?
    A: Yes, we can provide samples, but the customer will pay the freight.
    Q3: How do I start paying?
    Payment can be made by Bitcoin,T/T, wire transfer paypal
    Q4: How to confirm product quality before placing an order?
    A: You can get free samples of some products. You just have to pay the shipping fee or arrange for the sample to be sent to us by express.You can send us your product specifications and requirements and we will produce products according to your requirements.
    Q5: What is your MOQ?
    A: The minimum quantity we can order is 1 kilo.But usually we can accept a smaller quantity, say 100g, at the cost of 100% sample charge.
    Q6: Shipping Time?
    A: We ship the parcel out in 3-7 days and offer tracking No.. Shipping time is different to different country. Please consult.


    Company Profile

    Jinan Silk Road Trading Co., Ltd.  Henan Province, which has developed transportation. We are engaged in the development, marketing and sales of intermediates, Peptides, Ste roids, Sterol, chemicals and other products.

    Our products enjoy good reputation both at home and abroad. Our trade partners are around the world, mainly in America,Europe,Australia,South East Asia ,Middle East and South Africa. In order to serve customers well, the company has established special technical department and after-sale service department. We will make careful reply if you get any question.

    The company with all the employees will constantly purse excellent quality, perfect brand and our image, and adheres to our spirit of honesty, diligence, seeking truth and progress and insists on business philosophy of quality as life and service as soul. We will satisfy market demands by top products and better service, and will welcome market challenge forever.

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    Our advantage

    1. Own your own chemical plant

    2. Rich professional production experience

    3. Sample free and in stock, delivery

    4. Price, quality and service, we care about all your concerns

    5. Timely reply Keep in touch to save your time

    6. Easy customs clearance, we have all these controlsAll very good

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    ECHEMI Editorial Reference
    White SolidEzetimibe is ananti-hyperlipidemic drug used for lowering the plasma cholesterol levels. It is indicated as an adjunctive therapy to diet for the reduction of high-level total-C, LDL-C, and ApoB in patients suffering primary (heterozygous familial and non-familial) hypercholesterolemia. It is also used in combination therapy with HMG-CoA reductase inhibitors.Ezetimibe does not inhibit the cholesterol synthesis in the liver, or increase bile acid excretion.It takes effect throughactin
    Solid
    Ezetimibe is a beta-lactam that is azetidin-2-one which is substituted at 1, 3, and 4 by p-fluorophenyl, 3-(p-fluorophenyl)-3-hydroxypropyl, and 4-hydroxyphenyl groups, respectively (the 3R,3'S,4S enantiomer). It has a role as an anticholesteremic drug, an antilipemic drug and an antimetabolite. It is a member of azetidines, an organofluorine compound and a beta-lactam.|Ezetimibe is a lipid-lowering compound that inhibits intestinal cholesterol and phytosterol absorption. The discovery and research of this drug began in the early 1990s, after the intravenous administration of radiolabelled ezetimibe in rats revealed that it was being localized within enterocytes of the intestinal villi - this prompted studies investigating the effect of ezetimibe on intestinal cholesterol absorption. Ezetimibe is used as an adjunctive therapy to a healthy diet to lower cholesterol levels in primary hyperlipidemia, mixed hyperlipidemia, homozygous familial hypercholesterolemia (HoFH), and homozygous sitosterolemia (phytosterolemia). Unlike other classes of cholesterol-reducing compounds including statins and bile acid sequestrants, ezetimibe has a distinct mechanism of action involving the sterol transporter Niemann-Pick C1-Like 1 (NPC1L1), and is unique in that it does not affect the absorption of fat-soluble nutrients such as fat-soluble vitamins, triglycerides, or bile acids. In genetically NPC1L1-deficient mice, a 70% reduction in intestinal cholesterol absorption was seen, and these mice were insensitive to ezetimibe treatment - it was determined based on these findings that NPC1L1 plays an essential role in promoting intestinal cholesterol uptake via an ezetimibe-sensitive pathway. By interfering with the intestinal uptake of cholesterol and phytosterols, ezetimibe reduces the delivery of intestinal cholesterol to the liver.|Ezetimibe is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.|Ezetimibe is an inhibitor of intestinal cholesterol absorption that is widely used in the therapy of hypercholesterolemia, usually in combination with other agents. Ezetimibe therapy is associated with a low rate of serum aminotransferase elevations and clinically apparent liver injury due to ezetimibe occurs, but is rare.|Ezetimibe is an azetidinone derivative and a cholesterol absorption inhibitor with lipid-lowering activity. Ezetimibe appears to interact physically with cholesterol transporters at the brush border of the small intestine and inhibits the intestinal absorption of cholesterol and related phytosterols. As a result, ezetimibe causes a decrease in the level of blood cholesterol or an increase in the clearance of cholesterol from the bloodstream. Overall, the following effects observed are a reduction of hepatic cholesterol stores and a reduction of total cholesterol, LDL cholesterol, and other triglycerides in the blood.|An azetidine derivative and ANTICHOLESTEREMIC AGENT that inhibits intestinal STEROL absorption. It is used to reduce total CHOLESTEROL; LDL CHOLESTEROL, and APOLIPOPROTEINS B in the treatment of HYPERLIPIDEMIAS.

    Certificates

    Basic Info
    Product Name:

    Ezetimibe

    Other Name:

    2-Azetidinone,1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-,(3R,4S)-;2-Azetidinone,1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-,[3R-[3α(S*),4β]]-;(3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone;Sch 58235;Ezetimibe;(-)-Sch 58235;Zetia;Ezetrol;Ezta;Ezedoc;1-(4-Fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)azetidin-2-one;Ezentia

    CAS No.:

    163222-33-1

    Molecular Formula:

    C24H21F2NO3

    InChIKeys:

    InChIKey=OLNTVTPDXPETLC-XPWALMASSA-N

    Molecular Weight:

    409.43

    Exact Mass:

    409.43

    EC Number:

    1308068-626-2

    UNII:

    EOR26LQQ24

    DSSTox ID:

    DTXSID1044223

    NCI Thesaurus Code:

    C47529

    Color/Form:

    White solid

    ATC Code:

    C10B|C10AX09|C - Cardiovascular system

    HScode:

    29337900

    Characteristics
    PSA:

    60.8

    XLogP3:

    4

    Appearance:

    Solid

    Density:

    1.334±0.06 g/cm3(Predicted)

    Melting Point:

    164-166 °C

    Boiling Point:

    654.9±55.0 °C(Predicted)

    Flash Point:

    349.9±31.5 °C

    Refractive Index:

    1.624

    Water Solubility:

    H2O: Insoluble

    Storage Conditions:

    -20°C Freezer

    Vapor Pressure:

    1.5X10-14 mm Hg at 25 deg C (est)

    Specific rotation:

    D22 -33.9° (c = 3 in methanol)

    Henrys Law Constant:

    Henry's Law constant = 4.4X10-18 atm-cu m/mole at 25 °C (est)

    Dissociation Constants:

    pKa1 = 9.73 (phenol) (est)

    Collision Cross Section:

    213.6 Ų [M+Na]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

    Hazard Identification

    Classification of the substance or mixture

    Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H410 Very toxic to aquatic life with long lasting effects

    Precautionary statement(s)
    Prevention

    P273 Avoid release to the environment.

    Response

    P391 Collect spillage.

    Storage

    none

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    peptide,Weight loss peptide

    Location:

    jinan fenghuang guojiguangchang

    Year of Establishment:

    2024

    Company Profile
    10 Years' Manufacturer and Exporter of Chemicals
    we have more than 10 years of experience in manufacturing intermediates, Peptides, Sterol, chemicals and other products.
    Products Exported to Over 30 Countries
    Our products enjoy good reputation both at home and abroad. Our trade partners are around the world, mainly in America, Europe, Australia, Southeast Asia, the Middle East and South Africa.
    Call Us to Get More Details
    In order to serve customers well, the company has established special technical department and after-sale service department. We will make careful reply if you get any question. We look forward to cooperating with you soon.
  • Inquiry History
    6 Inquiries
    Country Product Purchase Quantity Date Posted
    India

    Ezetimibe

    5.00 KG Jan 22, 2024
    France

    Ezetimibe

    10 G Sep 29, 2026
    Pakistan

    Ezetimibe

    10 KG Oct 29, 2025
    United States

    Ezetimibe

    10 G Sep 16, 2025
    India

    Febuxostat

    5.00 KG Jan 22, 2024
    India

    Linagliptin

    5.00 KG Jan 22, 2024
    Post an enquiry for this product
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