DSIP 2mg 5mg 15mg Delta-Sleep Inducing Peptide/Dsip CAS 62568-57-4 Emideltide

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Detailed Introduction to DSIP Products

I. Basic Information

DSIP, short for Delta Sleep-Inducing Peptide, is a naturally occurring neuropeptide first discovered in rabbit cerebrospinal fluid in 1974. Composed of 9 amino acids (sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) with a molecular weight of approximately 848.8 daltons, it exhibits various biological activities such as regulating sleep, calming the nerves, and maintaining physiological rhythms.

As an endogenous peptide, DSIP does not directly induce sleep. Instead, it improves sleep quality, prolongs deep sleep cycles, and exerts indirect effects on the body’s stress response and emotional regulation by influencing the balance of neurotransmitters (e.g., gamma-aminobutyric acid, serotonin) in the central nervous system.

II. Mechanism of Action

The core mechanism of DSIP revolves around the regulation of the central nervous system, mainly including:

1. Sleep regulation: By binding to receptors in sleep-related brain regions such as the hypothalamus and brainstem, it optimizes sleep structure, reduces sleep latency, increases the proportion of slow-wave (deep) sleep, and decreases the frequency of sleep interruptions.

2. Sedation: It inhibits the overactivation of the hypothalamic-pituitary-adrenal (HPA) axis, reduces the secretion of stress hormones (e.g., cortisol), alleviates anxiety and tension, and produces a sedative effect without significant drowsiness.

3. Neuroprotection: Studies suggest that DSIP may protect nerve cells by inhibiting oxidative stress and inflammatory responses, with potential protective effects against brain damage and cognitive decline.

4. Endocrine regulation: It indirectly affects the secretion rhythms of hormones such as growth hormone and melatonin, participating in the maintenance of body metabolism and circadian rhythms.

III. Research Data and Application Scenarios

1. Preclinical studies:

◦ Animal experiments show that DSIP can significantly prolong deep sleep time in rats without disrupting normal sleep cycles (unlike sedatives, it does not cause next-day drowsiness or sleep structure damage).

◦ In stress models, DSIP reduces cortisol levels in rats, alleviates anxious behaviors, and improves stress-induced sleep disorders.

2. Clinical research and potential applications:

◦ Sleep disorders: Small-scale studies on patients with insomnia and sleep apnea syndrome indicate that DSIP can improve sleep efficiency, reduce nighttime awakenings, and has high safety.

◦ Stress-related diseases: In conditions such as chronic fatigue syndrome and post-traumatic stress disorder (PTSD), DSIP may alleviate symptoms by regulating the HPA axis.

IV. Product Parameters

• English Name: Delta Sleep-Inducing Peptide (DSIP)

• Amino Acid Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

• Molecular Weight: 848.8 g/mol

• CAS Number: 62568-67-4

• Purity Specification: ≥98% (HPLC-tested)

• Physical Form: White lyophilized powder, soluble in water or physiological saline

• Storage Conditions: Store at -20°C in a sealed, light-protected container; avoid repeated freeze-thaw cycles

V. Advantages and Precautions

1. Core Advantages:

◦ As a natural endogenous peptide, it has high biocompatibility and few side effects (unlike benzodiazepine sedatives, it carries no risk of addiction or respiratory depression).

◦ It regulates sleep rhythms without directly inhibiting the central nervous system, making it more suitable for improving chronic sleep disorders.

◦ It has potential  neuroprotective properties, enabling a wide range of applications.

2. Precautions:

◦ Currently, it is mainly in the research stage and not yet widely used clinically; use under professional guidance is required.

◦ Lyophilized powder must be stored strictly according to the specified conditions; reconstituted solutions should be used as soon as possible to avoid degradation.

VI. Research Prospects

Due to its unique sleep-regulating mechanism and favorable safety profile, DSIP has become a research hotspot in sleep medicine, neurodegenerative diseases, and stress-related fields. With the advancement of clinical trials, it is expected to be developed into a new peptide drug for treating chronic insomnia, anxiety, and neuroprotection, offering new options for improving body physiological rhythms and nerve function.

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